PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes (NCT05390892)
PRECIDENTD: PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes
🩺 Plain-English Summary (8th-Grade Level)
PRECIDENTD is a randomized, open label, pragmatic clinical trial designed to compare rates of the total number of cardiovascular, kidney, and death events among two alternative treatments for patients with type 2 diabetes (T2D) and either established atherosclerotic cardiovascular disease (ASCVD) or at high risk for ASCVD. To accomplish this objective, we will randomly assign 6,000 patients with established T2D and ASCVD or high-risk for ASCVD in a 1:1 allocation to sodium-glucose cotransporter-2 inhibitor (SGLT2i) or glucagon-like peptide-1 receptor agonists (GLP-1RA). Participants will be followed for the occurrence of the trial primary endpoint of the total (first and recurrent) number of episodes of myocardial infarction (MI), stroke, arterial revascularization, hospitalization for heart failure, development of end-stage kidney disease, kidney transplantation, and mortality, counting all events from randomization until end of study.
Who can join: Review the eligibility criteria below.
Location: Longwood Research LLC — Huntsville, Alabama
Age range: 40 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (36 Sites)
Showing the first 25 of 36 sites.
- Longwood Research LLC — Huntsville, Alabama
- HonorHealth Research & Innovation Institute — Scottsdale, Arizona
- Eastside Clinical Research Associates — Los Angeles, California
- Kendall South Medical Center, Inc — Miami, Florida
- South Florida Research Solutions, LLC — Pembroke Pines, Florida
- NSC Research, Inc. — Johns Creek, Georgia
- Herman Clinical Research — Suwanee, Georgia
- University of Illinois Chicago — Chicago, Illinois
- Rush University Medical Center — Hinsdale, Illinois
- University of Iowa — Iowa City, Iowa
- University of Kansas Medical Center — Fairway, Kansas
- Johns Hopkins School of Medicine — Baltimore, Maryland
- MedStar Union Memorial Hospital — Baltimore, Maryland
- MedStar Health Research Institute - Good Samaritan Hospital — Baltimore, Maryland
- Brigham and Women's Hospital — Boston, Massachusetts
- UMass Chan Medical School — Worcester, Massachusetts
- University of Michigan — Ann Arbor, Michigan
- Essentia Health — Duluth, Minnesota
- University of Minnesota — Minneapolis, Minnesota
- University of Missouri-Columbia — Columbia, Missouri
- University of Nebraska Medical Center — Omaha, Nebraska
- Naomi Berrie Diabetes Center at New York Presbyterian-Columbia University — New York, New York
- Atrium Health Family Medicine Research Department — Charlotte, North Carolina
- Duke University Hospital — Durham, North Carolina
- Wooster Heart Group — Wooster, Ohio
📞 Contact the Study Coordinator
Phone: (617) 732-8790
Email: PRECIDENTDccc@bwh.harvard.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.