Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome (NCT05421208)
🩺 Plain-English Summary (8th-Grade Level)
The term post-acute COVID-19 syndrome or Long COVID is a disabling syndrome that persists beyond the 3-month convalescence period after COVID-19 infections. This syndrome affects mostly women (\~80%), present with chronic tachycardia and Orthostatic intolerance symptoms without any identifiable cause. In addition, non-specific symptoms such as fatigue, headache, and "brain fog", commonly described in POTS patients are also present in this novel condition, recently named post-COVID-19 tachycardia syndrome, POTS variant. Reduced Vagal activity and unresolved inflammation is post-COVID-19 POTS is hypothesized as the cause of Long COVID
Who can join: Review the eligibility criteria below.
Location: Vanderbilt University Medical Center — Nashville, Tennessee
Age range: 18 Years
🧪 Interventions in This Study
- Levels of inflammatory cytokine ( IL-6) in post-COVID-19 POTS and controls (DIAGNOSTIC_TEST)
- Levels of inflammatory cytokine ( IL-6) in controls (DIAGNOSTIC_TEST)
- Effect on inflammation after chronic PNS stimulation (DIAGNOSTIC_TEST)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Vanderbilt University Medical Center — Nashville, Tennessee
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Post-acute COVID-19 Syndrome
- A Study of Positive Emotions With Long COVID-19 — Sacramento, California
- Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I) — Bethesda, Maryland
- Harnessing Optimism and Perseverance in the Face of Long COVID-Español — New York, New York
- Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research — Delafield, Wisconsin
- Dietary Intervention to Mitigate Post-Acute COVID-19 Syndrome — Baltimore, Maryland
Explore by condition: All Post-acute COVID-19 Syndrome clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.