A Study of JNJ-90014496 in Participants With B-Cell Non-Hodgkin Lymphoma (NCT05421663)
A Phase 1b/2, Multicenter, Open-label, Study of JNJ-90014496, an Autologous CD19/CD20 Bi-specific CAR-T Cell Therapy in Adult Participants With B-cell Non-Hodgkin Lymphoma
🩺 Plain-English Summary (8th-Grade Level)
This is a Phase 1b/2, multicenter, open-label, study of JNJ-90014496, an autologous dual targeting chimeric antigen receptor (CAR) T-cell therapy targeting both cluster of differentiation (CD) CD20 and CD19, for the treatment of adult participants with relapsed or refractory (r/r) B-Cell non-Hodgkin lymphoma (B-NHL) or frontline high-risk diffuse large B-cell lymphoma (DLBCL).
Who can join: Review the eligibility criteria below.
Location: City of Hope — Duarte, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (32 Sites)
Showing the first 25 of 32 sites.
- City of Hope — Duarte, California
- Colorado Blood Cancer Institute — Denver, Colorado
- University of Iowa Hospital and Clinics — Iowa City, Iowa
- University of Kentucky Medical Center — Lexington, Kentucky
- Rutgers Cancer Institute of New Jersey — Piscataway, New Jersey
- Levine Cancer Institute — Charlotte, North Carolina
- University Hospitals Cleveland Medical Center — Cleveland, Ohio
- University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania
- Greco Hainesworth Tennessee Oncology Centers for Research — Nashville, Tennessee
- Sarah Cannon Research Institute — Nashville, Tennessee
- St. David's South Austin Medical Center — Austin, Texas
- MD Anderson Cancer Center — Houston, Texas
- Texas Transplant Institute — San Antonio, Texas
- Swedish Cancer Institute — Seattle, Washington
- St Vincents Hospital Melbourne — Fitzroy,
- The Alfred Hospital — Melbourne,
- Fiona Stanley Hospital — Murdoch,
- Calvary Mater Newcastle Hospital — Waratah,
- Princess Margaret Cancer Centre University Health Network — Toronto, Ontario
- Rigshospitalet — Copenhagen,
- Odense University Hospital — Odense,
- Erasmus MC — Rotterdam,
- UMC Utrecht — Utrecht,
- Seoul National University Hospital — Seoul,
- Asan Medical Center — Seoul,
📞 Contact the Study Coordinator
Phone: (800) 826-4673
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.