๐๏ธ Verified NIH Record โข Updated 2024-03-13
OT-101 in Combination With Pembrolizumab in Subjects With Malignant Pleural Mesothelioma Failing to Respond to Checkpoint Inhibition (NCT05425576)
Phase 2 Trial of TGF-ฮฒ Inhibition (OT-101) With Anti-PD-1 (Pembrolizumab) in Patients With Malignant Pleural Mesothelioma (MPM) Failing to Achieve or Maintain Response to Checkpoint Inhibition
๐ก Not Yet Recruiting Phase2 ๐ Investigational Drug / Biologic Sponsor: Oncotelic Inc.
๐ฉบ Plain-English Summary (8th-Grade Level)
This is a study of OT-101, a TGF-b2 inhibitor in combination of pembrolizumab in patients with malignant pleural mesothelioma. Both efficacy assessment, and safety and tolerability of various dose of OT-101 in combination of pembrolizumab are evaluated.
Who can join: Review the eligibility criteria below.
Location: University of Pennsylvania โ Philadelphia, Pennsylvania
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (1 Sites)
- University of Pennsylvania โ Philadelphia, Pennsylvania
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Malignant Pleural Mesothelioma
- A Study of Pembrolizumab and Radiation Therapy in People With Mesothelioma โ Basking Ridge, New Jersey
- A Study of Nivolumab and Chemotherapy Followed by Surgery for Mesothelioma โ Basking Ridge, New Jersey
- Using E-Nose Technology to Measure Response to Treatment in People With Malignant Pleural Mesothelioma โ Basking Ridge, New Jersey
Explore by condition: All Malignant Pleural Mesothelioma clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.