Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases (NCT05438212)
A Randomized Phase III Trial of Pre-Operative Compared to Post-Operative Stereotactic Radiosurgery in Patients With Resectable Brain Metastases
🩺 Plain-English Summary (8th-Grade Level)
This phase III trial compares the usual treatment of surgery after stereotactic radiosurgery (SRS) to receiving SRS before surgery in treating patients with cancer that has spread to the brain (brain metastases). Stereotactic radiosurgery is a type of radiation therapy that delivers a high dose of radiation to target tumors and minimizes effect on normal surrounding brain tissue. The combination of surgery and radiation may stop the tumor from growing for a few months or longer and may reduce symptoms of brain metastases. This study investigates whether treating with SRS before surgery may be better than SRS after surgery in reducing the possibility of the tumor coming back, reducing or preventing the cancer from spreading to other areas of the brain and reducing the risk of scarring on the brain from radiation.
Who can join: Review the eligibility criteria below.
Location: Saint Joseph's Hospital and Medical Center — Phoenix, Arizona
Age range: 18 Years
🧪 Interventions in This Study
- Brain Surgery (PROCEDURE)
- Quality-of-Life Assessment (OTHER)
- Questionnaire Administration (OTHER)
- Stereotactic Radiosurgery (RADIATION)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (216 Sites)
Showing the first 25 of 216 sites.
- Saint Joseph's Hospital and Medical Center — Phoenix, Arizona
- Banner University Medical Center - Tucson — Tucson, Arizona
- University of Arizona Cancer Center-North Campus — Tucson, Arizona
- Kaiser Permanente-Anaheim — Anaheim, California
- Sutter Auburn Faith Hospital — Auburn, California
- Sutter Cancer Centers Radiation Oncology Services-Auburn — Auburn, California
- Kaiser Permanente-Bellflower — Bellflower, California
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care — Irvine, California
- Kaiser Permanente Los Angeles Medical Center — Los Angeles, California
- Memorial Medical Center — Modesto, California
- Kaiser Permanente-Ontario — Ontario, California
- Saint Joseph Hospital - Orange — Orange, California
- UC Irvine Health/Chao Family Comprehensive Cancer Center — Orange, California
- Stanford Cancer Institute Palo Alto — Palo Alto, California
- Sutter Cancer Centers Radiation Oncology Services-Roseville — Roseville, California
- Sutter Roseville Medical Center — Roseville, California
- Sutter Medical Center Sacramento — Sacramento, California
- University of California Davis Comprehensive Cancer Center — Sacramento, California
- California Pacific Medical Center-Pacific Campus — San Francisco, California
- UCSF Medical Center-Parnassus — San Francisco, California
- Sutter Pacific Medical Foundation — Santa Rosa, California
- Sutter Solano Medical Center/Cancer Center — Vallejo, California
- UM Sylvester Comprehensive Cancer Center at Coral Gables — Coral Gables, Florida
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach — Deerfield Beach, Florida
- UM Sylvester Comprehensive Cancer Center at Doral — Doral, Florida
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Metastatic Malignant Neoplasm in the Brain
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- Neuropsychological Care for Maintaining Quality of Life After Radiation Therapy in Patients With Brain Metastases — Columbus, Ohio
- Stereotactic Radiosurgery Compared to Observation in Treating Patients With Brain Metastases — Houston, Texas
- Trametinib With or Without Whole Brain Radiation Therapy in Treating Patients With Brain Metastases — Columbus, Ohio
- nTMS in Planning Stereotactic Radiosurgery in Patients With Brain Metastases in the Motor Cortex — Houston, Texas
Explore by condition: All Metastatic Malignant Neoplasm in the Brain clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.