Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study (NCT05447559)
Multicentre, Adaptive, Double-blind, Three-arm, Placebo-controlled, Noninferiority Trial Examining Antimicrobial Prophylaxis Duration in Cardiac Surgery
🩺 Plain-English Summary (8th-Grade Level)
This multicentre, adaptive, pragmatic, double-blind, three-arm, placebo-controlled, randomised, non-inferiority clinical trial will compare the incidence of surgical site infection and other healthcare associated infections, health economic and microbiological impact after intraoperative only (Arm A), to 24 hours (Arm B) and, to 48 hours (Arm C) of IV cefazolin and placebo postoperative surgical antimicrobial prophylaxis in patients undergoing cardiac surgery
Who can join: Review the eligibility criteria below.
Location: UT Southwestern Medical Centre — Dallas, Texas
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (27 Sites)
Showing the first 25 of 27 sites.
- UT Southwestern Medical Centre — Dallas, Texas
- Westmead Hospital — Sydney, New South Wales
- St George Hospital — Sydney, New South Wales
- The Prince Charles Hospital — Brisbane, Queensland
- Princess Alexandra Hospital — Brisbane, Queensland
- St Andrew's War Memorial Hospital — Brisbane, Queensland
- Royal Adelaide Hospital — Adelaide, South Australia
- Flinders Medical Centre — Adelaide, South Australia
- Flinders Private — Adelaide, South Australia
- Royal Hobart Hospital — Hobart, Tasmania
- The Alfred Hospital — Melbourne, Victoria
- The Royal Melbourne Hospital — Melbourne, Victoria
- Austin Health — Melbourne, Victoria
- Epworth HealthCare — Melbourne, Victoria
- Cabrini Health — Melbourne, Victoria
- Victorian Heart Hospital — Melbourne, Victoria
- Sir Charles Gairdner — Nedlands, Western Australia
- St John of God Subiaco Hospital — Perth, Western Australia
- Fiona Stanley Hospital — Perth, Western Australia
- St Vincent's Hospital — Melbourne,
- Halifax Infirmary — Halifax, Nova Scotia
- IJN — Kuala Lumpur,
- UMMC — Kuala Lumpur,
- Christchurch Hospital — Christchurch,
- Waikato Hospital — Hamilton,
📞 Contact the Study Coordinator
Phone: 9903 0016
Email: paige.druce@monash.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- A Stratified, Multi-ARm, muLti-site Randomised Platform Trial Aiming to Reduce the INcidence of Post-operative SSI — Abomey-Calavi,
- PRevention Of Trauma-related Infections Through an Embedded Clinical Trials Network — Houston, Texas
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.