Who is eligible for clinical trial NCT05450692?

Participants must meet protocol criteria for Advanced or Metastatic Non-Small Cell Lung Cancer. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT05450692 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-07-10

A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy (NCT05450692)

A Phase III, Open-label, Randomised, Multicentre Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer Without Actionable Genomic Alterations, and Whose Disease Has Progressed On or After Prior Anti-PD-(L)1 Therapy and Platinum-based Chemotherapy: LATIFY

🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: AstraZeneca

🩺 Plain-English Summary (8th-Grade Level)

This study will assess the efficacy and safety of the combination of ceralasertib and durvalumab versus standard of care docetaxel in patients with locally advanced and metastatic NSCLC after progression on prior anti-PD-(L)1 therapy and platinum-based chemotherapy.

Who can join: Review the eligibility criteria below.

Location: Research Site — Mobile, Alabama

Age range: 18 Years to 130 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (191 Sites)

Showing the first 25 of 191 sites.

Research Site — Mobile, Alabama
Research Site — Chandler, Arizona
Research Site — Los Alamitos, California
Research Site — Los Angeles, California
Research Site — Whittier, California
Research Site — Jacksonville, Florida
Research Site — Orlando, Florida
Research Site — Athens, Georgia
Research Site — Atlanta, Georgia
Research Site — Fort Wayne, Indiana
Research Site — Baltimore, Maryland
Research Site — Bethesda, Maryland
Research Site — Rockville, Maryland
Research Site — Hattiesburg, Mississippi
Research Site — St Louis, Missouri
Research Site — Omaha, Nebraska
Research Site — Reno, Nevada
Research Site — Charlotte, North Carolina
Research Site — Winston-Salem, North Carolina
Research Site — Canton, Ohio
Research Site — Cleveland, Ohio
Research Site — Allentown, Pennsylvania
Research Site — York, Pennsylvania
Research Site — Houston, Texas
Research Site — Huntsville, Texas

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

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💡 How to Participate

Check the checklist above to see if you may qualify.
Review the official NIH record below to find the coordinating site.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗