A Study to Learn About How 20-Valent Pneumococcal Conjugate Vaccine Works in a Real-world Setting (NCT05452941)
A Phase 4 Study Using a Test-Negative Design to Evaluate the Effectiveness of a 20-valent Pneumococcal Conjugate Vaccine Against Vaccine-type Radiologically-confirmed Community-acquired Pneumonia in Adults >/= 65 Years of Age
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to learn about how well the 20-valent pneumococcal conjugate vaccine (20vPnC) works against radiologically-confirmed community-acquired pneumonia (RAD+CAP) due to the 7 new serotypes (types of a bacteria called Streptococcus pneumoniae that cause pneumonia) included in 20vPnC vaccine. This study is seeking participants who: * are male or female ≥65 years of age. * are hospitalized with physician suspicion of community acquired pneumonia (CAP). * have pneumonia confirmed with imaging like a chest x-ray Participants will be asked to provide demographic and medical history information, and to provide a urine sample that will be used to test for pneumonia caused by specific strains of a bacteria called Streptococcus pneumoniae. We will compare the proportion of participants who have pneumonia caused by specific strains of the bacteria Streptococcus pneumoniae and were previously vaccinated with 20vPnC with the proportion of participants who have pneumonia caused by something other than vaccine type Streptococcus pneumoniae and have been vaccinated with 20vPnC. Participants will actively take part in the study for about 1-2 days. Information on participant's illness and hospitalization details will be collected through day 30 of their hospitalization through medical chart review.
Who can join: Review the eligibility criteria below.
Location: El Centro Regional Medical Center — El Centro, California
Age range: 65 Years
🧪 Interventions in This Study
- Diagnostic test on urine samples (DIAGNOSTIC_TEST)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (54 Sites)
Showing the first 25 of 54 sites.
- El Centro Regional Medical Center — El Centro, California
- Kaiser Permanente Fontana Medical Center — Fontana, California
- Kaiser Permanente West Los Angeles Medical Center — Los Angeles, California
- Kaiser Permanente Vaccine Study Center — Oakland, California
- Kaiser Permanente Oakland Medical Center — Oakland, California
- Kaiser Permanente Ontario Medical Center — Ontario, California
- Southern California Permanente Medical Group (SCPMG) — Pasadena, California
- Kaiser Permanente Riverside Medical Center — Riverside, California
- Kaiser Permanente Roseville Medical Center — Roseville, California
- Kaiser Permanente South Sacramento Medical Center — Sacramento, California
- Kaiser Permanente Sacramento Medical Center — Sacramento, California
- Kaiser Permanente Zion Medical Center — San Diego, California
- Kaiser Permanente San Diego Medical Center — San Diego, California
- Kaiser Permanente Santa Clara Medical Center — Santa Clara, California
- Kaiser Permanente South San Francisco Medical Center — South San Francisco, California
- Kaiser Permanente Walnut Creek Medical Center — Walnut Creek, California
- Starling Physicians — Hartford, Connecticut
- MedStar Washington Hospital Center — Washington D.C., District of Columbia
- Emory Children's Center - Vaccine Research Clinic (ECC-VRC) — Atlanta, Georgia
- Emory University Hospital — Atlanta, Georgia
- University of Louisville School of Medicine, Division of Infectious Diseases — Louisville, Kentucky
- Robley Rex VA Medical Center — Louisville, Kentucky
- UofL Health, Mary & Elizabeth Hospital — Louisville, Kentucky
- Norton Audubon Hospital — Louisville, Kentucky
- Norton Brownsboro Hospital — Louisville, Kentucky
📞 Contact the Study Coordinator
Phone: (800) 718-1021
Email: ClinicalTrials.gov_Inquiries@pfizer.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Study of Lung Proteins in Patients With Pneumonia — Bethesda, Maryland
- Performance of New Diagnostic Methods in Older Adults With Pneumonia — Columbus, Ohio
- How OMT Benefits Newly Diagnosed Patients With Respiratory Illness When Given Alongside Other Standard Care. — Bloomsburg, Pennsylvania
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Explore by condition: All Pneumonia clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.