A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Multiple Myeloma That Returns After Treatment or is Resistant to Treatment (NCT05455320)
A Phase 3 Randomized Study Comparing Talquetamab SC in Combination With Daratumumab SC and Pomalidomide (Tal-DP) or Talquetamab SC in Combination With Daratumumab SC (Tal-D) Versus Daratumumab SC, Pomalidomide and Dexamethasone (DPd), in Participants With Relapsed or Refractory Multiple Myeloma Who Have Received at Least 1 Prior Line of Therapy
🩺 Plain-English Summary (8th-Grade Level)
The purpose of the study is to compare the efficacy of talquetamab subcutaneous(ly) (SC) in combination with daratumumab SC and pomalidomide (Tal-DP) and talquetamab SC in combination with daratumumab SC (Tal-D), respectively, with daratumumab SC in combination with pomalidomide and dexamethasone (DPd).
Who can join: Review the eligibility criteria below.
Location: The University of Arizona Cancer Center — Tucson, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (216 Sites)
Showing the first 25 of 216 sites.
- The University of Arizona Cancer Center — Tucson, Arizona
- University of Arkansas for Medical Sciences — Little Rock, Arkansas
- Norwalk Hospital-oncology — Norwalk, Connecticut
- MedStar Georgetown University Hospital — Washington D.C., District of Columbia
- George Washington University — Washington D.C., District of Columbia
- Memorial Healthcare System — Hollywood, Florida
- University of Miami Health System — Miami, Florida
- University Of Illinois — Chicago, Illinois
- University of Kansas — Westwood, Kansas
- Tulane University Hospital & Clinics — New Orleans, Louisiana
- Ochsner Health System — New Orleans, Louisiana
- Johns Hopkins University — Baltimore, Maryland
- Massachusetts General — Boston, Massachusetts
- Boston University Medical Center — Boston, Massachusetts
- University of Massachusetts Medical School — Worcester, Massachusetts
- University of Michigan Health System — Ann Arbor, Michigan
- University Of Minnesota — Minneapolis, Minnesota
- University of Mississippi Medical Center — Jackson, Mississippi
- Washington University School Of Medicine — St Louis, Missouri
- Rutgers Cancer Institute of New Jersey — New Brunswick, New Jersey
- NYU Langone Health — New York, New York
- SUNY Upstate Medical University — Syracuse, New York
- University of North Carolina — Chapel Hill, North Carolina
- Levine Cancer Institute, Carolinas HealthCare System — Charlotte, North Carolina
- Novant Health 1 — Charlotte, North Carolina
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Multiple Myeloma Outcomes Based on Maintenance Therapy Post Autologous Stem Cell Transplant — Tampa, Florida
- MagnetisMM-3: Study Of Elranatamab (PF-06863135) Monotherapy in Participants With Multiple Myeloma Who Are Refractory to at Least One PI, One IMiD and One Anti-CD38 mAb — Beverly Hills, California
- A Study of CLN-619 (Anti-MICA/MICB Antibody) in Patients With Relapsed and Refractory Multiple Myeloma — Phoenix, Arizona
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Explore by condition: All Multiple Myeloma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.