๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2025-09-18

A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation (NCT05485974)

A Phase 1, Open Label, Dose Escalation of HBI-2438 in Patients With Advanced Malignant Solid Tumors Harboring KRAS G12C Mutation

๐Ÿ”ต Active, Not Recruiting Phase1 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: HUYABIO International, LLC.

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS G12C mutation to determine the maximum tolerated dose and recommended Phase II dose of HBI-2438 and characterize its pharmacokinetic profile.

Who can join: Review the eligibility criteria below.

Location: California Cancer Associates for Research and Excellence, Inc. (cCare) โ€” Encinitas, California

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (14 Sites)

  • California Cancer Associates for Research and Excellence, Inc. (cCare) โ€” Encinitas, California
  • The Oncology Institute of Hope and Innovation โ€” Glendale, California
  • The Oncology Institute of Hope and Innovation โ€” Long Beach, California
  • The Oncology Institute of Hope and Innovation โ€” Pasadena, California
  • California Cancer Associates for Research and Excellence, Inc. (cCare) โ€” San Marcos, California
  • The Oncology Institute of Hope and Innovation โ€” Santa Ana, California
  • Sarcoma Oncology โ€” Santa Monica, California
  • Innovative Clinical Research Institute (ICRI) โ€” Whittier, California
  • The Oncology Institute of Hope and Innovation โ€” Whittier, California
  • BRCR Medical Center โ€” Plantation, Florida
  • Michigan Center of Medical Research โ€” Farmington Hills, Michigan
  • Alliance for Multispecialty Research, LLC โ€” Kansas City, Missouri
  • Gabrail Cancer Center โ€” Canton, Ohio
  • Pan American Center for Oncology Trials (PanOncology Trials) โ€” Rio Piedras, Puerto Rico

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Lung Cancer clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—