๐๏ธ Verified NIH Record โข Updated 2025-09-18
A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation (NCT05485974)
A Phase 1, Open Label, Dose Escalation of HBI-2438 in Patients With Advanced Malignant Solid Tumors Harboring KRAS G12C Mutation
๐ต Active, Not Recruiting Phase1 ๐ Investigational Drug / Biologic Sponsor: HUYABIO International, LLC.
๐ฉบ Plain-English Summary (8th-Grade Level)
A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS G12C mutation to determine the maximum tolerated dose and recommended Phase II dose of HBI-2438 and characterize its pharmacokinetic profile.
Who can join: Review the eligibility criteria below.
Location: California Cancer Associates for Research and Excellence, Inc. (cCare) โ Encinitas, California
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (14 Sites)
- California Cancer Associates for Research and Excellence, Inc. (cCare) โ Encinitas, California
- The Oncology Institute of Hope and Innovation โ Glendale, California
- The Oncology Institute of Hope and Innovation โ Long Beach, California
- The Oncology Institute of Hope and Innovation โ Pasadena, California
- California Cancer Associates for Research and Excellence, Inc. (cCare) โ San Marcos, California
- The Oncology Institute of Hope and Innovation โ Santa Ana, California
- Sarcoma Oncology โ Santa Monica, California
- Innovative Clinical Research Institute (ICRI) โ Whittier, California
- The Oncology Institute of Hope and Innovation โ Whittier, California
- BRCR Medical Center โ Plantation, Florida
- Michigan Center of Medical Research โ Farmington Hills, Michigan
- Alliance for Multispecialty Research, LLC โ Kansas City, Missouri
- Gabrail Cancer Center โ Canton, Ohio
- Pan American Center for Oncology Trials (PanOncology Trials) โ Rio Piedras, Puerto Rico
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.