๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-06-30

First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (NCT05489237)

A FIRST-IN-HUMAN (FIH) STUDY OF IDRX-42 IN PARTICIPANTS WITH METASTATIC AND/OR UNRESECTABLE GASTROINTESTINAL STROMAL TUMORS (GIST)

๐Ÿ”ต Active, Not Recruiting Phase1 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: IDRX, Inc., a wholly owned subsidiary of GSK, LLC

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This is the first clinical trial of IDRX-42. The study is designed to evaluate the safety, tolerability, PK, and preliminary antitumor activity of IDRX-42 in adult participants with advanced (metastatic and/or surgically unresectable) GIST.

Who can join: Review the eligibility criteria below.

Location: GSK Investigational Site โ€” Miami, Florida

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (31 Sites)

Showing the first 25 of 31 sites.

  • GSK Investigational Site โ€” Miami, Florida
  • GSK Investigational Site โ€” Chicago, Illinois
  • GSK Investigational Site โ€” Boston, Massachusetts
  • GSK Investigational Site โ€” St Louis, Missouri
  • GSK Investigational Site โ€” New York, New York
  • GSK Investigational Site โ€” Portland, Oregon
  • GSK Investigational Site โ€” Philadelphia, Pennsylvania
  • GSK Investigational Site โ€” Houston, Texas
  • GSK Investigational Site โ€” Leuven,
  • GSK Investigational Site โ€” Beijing,
  • GSK Investigational Site โ€” Guangzhou,
  • GSK Investigational Site โ€” Wuhan,
  • GSK Investigational Site โ€” Bordeaux,
  • GSK Investigational Site โ€” Lyon,
  • GSK Investigational Site โ€” Marseille,
  • GSK Investigational Site โ€” Villejuif,
  • GSK Investigational Site โ€” Berlin,
  • GSK Investigational Site โ€” Essen,
  • GSK Investigational Site โ€” Milan,
  • GSK Investigational Site โ€” Chiba,
  • GSK Investigational Site โ€” Kanagawa,
  • GSK Investigational Site โ€” Tokyo,
  • GSK Investigational Site โ€” Amsterdam,
  • GSK Investigational Site โ€” Rotterdam,
  • GSK Investigational Site โ€” Seongnam-si Gyeonggi-do,

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—