๐๏ธ Verified NIH Record โข Updated 2026-06-30
First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (NCT05489237)
A FIRST-IN-HUMAN (FIH) STUDY OF IDRX-42 IN PARTICIPANTS WITH METASTATIC AND/OR UNRESECTABLE GASTROINTESTINAL STROMAL TUMORS (GIST)
๐ต Active, Not Recruiting Phase1 ๐ Investigational Drug / Biologic Sponsor: IDRX, Inc., a wholly owned subsidiary of GSK, LLC
๐ฉบ Plain-English Summary (8th-Grade Level)
This is the first clinical trial of IDRX-42. The study is designed to evaluate the safety, tolerability, PK, and preliminary antitumor activity of IDRX-42 in adult participants with advanced (metastatic and/or surgically unresectable) GIST.
Who can join: Review the eligibility criteria below.
Location: GSK Investigational Site โ Miami, Florida
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (31 Sites)
Showing the first 25 of 31 sites.
- GSK Investigational Site โ Miami, Florida
- GSK Investigational Site โ Chicago, Illinois
- GSK Investigational Site โ Boston, Massachusetts
- GSK Investigational Site โ St Louis, Missouri
- GSK Investigational Site โ New York, New York
- GSK Investigational Site โ Portland, Oregon
- GSK Investigational Site โ Philadelphia, Pennsylvania
- GSK Investigational Site โ Houston, Texas
- GSK Investigational Site โ Leuven,
- GSK Investigational Site โ Beijing,
- GSK Investigational Site โ Guangzhou,
- GSK Investigational Site โ Wuhan,
- GSK Investigational Site โ Bordeaux,
- GSK Investigational Site โ Lyon,
- GSK Investigational Site โ Marseille,
- GSK Investigational Site โ Villejuif,
- GSK Investigational Site โ Berlin,
- GSK Investigational Site โ Essen,
- GSK Investigational Site โ Milan,
- GSK Investigational Site โ Chiba,
- GSK Investigational Site โ Kanagawa,
- GSK Investigational Site โ Tokyo,
- GSK Investigational Site โ Amsterdam,
- GSK Investigational Site โ Rotterdam,
- GSK Investigational Site โ Seongnam-si Gyeonggi-do,
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.