Who is eligible for clinical trial NCT05499013?

Participants must meet protocol criteria for Polycythemia Vera. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT05499013 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2025-12-17

Study to Assess SLN124 in Patients With Polycythemia Vera (NCT05499013)

Phase 1/2 Study With an Open-label Dose Escalation Phase Followed by a Randomized, Double-blind Phase of SLN124 in Patients With Polycythemia Vera

🔵 Active, Not Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic Sponsor: Silence Therapeutics plc

🩺 Plain-English Summary (8th-Grade Level)

This is a Phase 1/2, multicenter study with an open-label dose escalation followed by a randomized placebo controlled and double-blind phase of SLN124 in adult patients with Polycythemia Vera (PV) to assess the safety, tolerability, efficacy, pharmacokinetic (PK), and Pharmacodynamic (PD) response of SLN124.

Who can join: Review the eligibility criteria below.

Location: Research Site — Hammond, Louisiana

Age range: 18 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (28 Sites)

Showing the first 25 of 28 sites.

Research Site — Hammond, Louisiana
Research Site — Buffalo, New York
Research Site — New York, New York
Research Site — Columbus, Ohio
Research Site — Huntsville, Texas
Research Site — Benowa,
Research Site — Hobart,
Research Site — Kurralta Park,
Research Site 2 — Melbourne,
Research Site — Melbourne,
Linear Clinical Research — Nedlands,
Research Site — Richmond,
Research Site 2 — Plovdiv,
Research Site — Plovdiv,
Research Site — Toronto,
Research Site — Freiburg im Breisgau,
Research Site — Hanover,
Research Site — Alessandria,
Research Site — Meldola,
Research Site — Johor Bahru,
Research Site — Kuala Terengganu,
Research Site — Kuantan,
Research Site — Kuching,
Research Site — Gdansk,
Research Site — Katowice,

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

More studies in Polycythemia Vera

A Phase 3 Study of Rusfertide in Patients With Polycythemia Vera — Mobile, Alabama
Study to Evaluate the Long-term Safety of Rusfertide (PTG-300) in Subjects With Polycythemia Vera — Covington, Louisiana
KRT-232 Compared to Ruxolitinib in Patients With Phlebotomy-Dependent Polycythemia Vera — Birmingham, Alabama
A Study to Assess Efficacy, Safety, and Tolerability of P1101 in Adult Patients With PV — Jacksonville, Florida
A ELN-Multicenter Study on Phenotypic Evolution and Clinical Outcomes — Rochester, Minnesota

Explore by condition: All Polycythemia Vera clinical trials

💡 How to Participate

Check the checklist above to see if you may qualify.
Review the official NIH record below to find the coordinating site.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗