🏛️ Verified NIH Record • Updated 2026-02-01
Reduced-dose Botox for Urgency Incontinence Among Elder Females (NCT05512039)
Reduced-dose onabotuLinumtoxinA for Urgency Incontinence Among Elder Females (RELIEF): A Randomized Controlled Comparative Effectiveness Trial With Embedded Qualitative and Costing Analyses
🔵 Active, Not Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic Sponsor: Dartmouth-Hitchcock Medical Center
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to study the treatment of urgency urinary incontinence (UUI), specifically among women 70 years and older, by comparing reduced versus standard dose of onabotulinumtoxinA (BTX; trade name BOTOX(c)) injection in the bladder.
Who can join: Review the eligibility criteria below.
Location: University of Alabama - Birmingham — Birmingham, Alabama
Age range: 70 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (7 Sites)
- University of Alabama - Birmingham — Birmingham, Alabama
- Kaiser Permanente Medical Group — San Diego, California
- University of Nebraska Medical Center — Omaha, Nebraska
- Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire
- Oregon Health & Science University — Portland, Oregon
- University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania
- University of Texas Southwestern Medical Center — Dallas, Texas
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Add-On ZIDA Sock Therapy for Overactive Bladder — Charleston, South Carolina
- Standard Injections Versus Reduced Injections for Intravesical onabotulinumtoxinA Treatment of Overactive Bladder — Bethesda, Maryland
Explore by condition: All Overactive Bladder clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.