🏛️ Verified NIH Record • Updated 2026-01-15

A Study of Botensilimab (AGEN1181) for the Treatment of Advanced Melanoma (NCT05529316)

A Multicohort, Open Label, Phase 2 Study of Botensilimab (AGEN1181) for Treatment of Advanced Melanoma Refractory to Prior Checkpoint Inhibitor Therapy

🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Agenus Inc.

🩺 Plain-English Summary (8th-Grade Level)

This study is an open-label, 2-part, Phase 2, multicenter study to evaluate the efficacy, safety, tolerability, and pharmacokinetic profiles of botensilimab as monotherapy and in combination with balstilimab in participants with advanced cutaneous melanoma refractory to checkpoint inhibitor therapy.

Who can join: Review the eligibility criteria below.

Location: Scottsdale Healthcare Hospitals DBA HonorHealth — Scottsdale, Arizona

Age range: 18 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (51 Sites)

Showing the first 25 of 51 sites.

  • Scottsdale Healthcare Hospitals DBA HonorHealth — Scottsdale, Arizona
  • Virginia K. Crosson Cancer Center at St. Jude Medical Center — Fullerton, California
  • Providence Saint John's Health Center — Santa Monica, California
  • Yale University School of Medicine - Yale Cancer Center — New Haven, Connecticut
  • Georgetown University Medical Center — Washington D.C., District of Columbia
  • Dana-Farber Cancer Institute — Boston, Massachusetts
  • John Theurer Cancer Center at Hackensack University Medical Center — Hackensack, New Jersey
  • Universitair Ziekenhuis Brussel — Jette,
  • Oncosite - Centro de Pesquisa Clinica Em Oncologia — Ijuí,
  • Centro de Pesquisas Clinicas da Fundação Doutor Amaral Carvalho — Jaú,
  • Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa — Porto Alegre,
  • INCA II - Instituto Nacional de Cancer Jose Alencar Gomes da Silva — Rio de Janeiro,
  • Hospital Sirio Libanes — São Paulo,
  • Real e Benemerita Associaçao Portuguesa de Beneficencia - A Beneficencia Portuguesa de Sao Paulo — São Paulo,
  • Hospital A.C. Camargo Cancer Center — São Paulo,
  • CHU Amiens Picardie - Hopital Sud — Amiens,
  • CHU Grenoble-Alpes - Hopital Michallon — La Tronche,
  • Centre Leon Berard — Lyon,
  • CHU de Nantes — Nantes,
  • AP-HP Hopital Saint-Louis — Paris,
  • Centre Eugene Marquis — Rennes,
  • Gustave Roussy — Villejuif,
  • Universitaetsklinikum Essen — Essen,
  • Universitaetsklinikum Hamburg-Eppendorf — Hamburg,
  • Universitaetsklinikum Heidelberg — Heidelberg,

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗