🏛️ Verified NIH Record • Updated 2026-08-04
A Study Evaluating the Efficacy and Safety of Cevostamab in Prior B Cell Maturation Antigen (BCMA)-Exposed Participants With Relapsed/Refractory Multiple Myeloma (NCT05535244)
A Phase I/II, Open-Label, Multi-Cohort Study to Evaluate the Efficacy and Safety of Cevostamab in Prior B Cell Maturation Antigen-Exposed Patients With Relapsed/Refractory Multiple Myeloma
🔵 Active, Not Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic Sponsor: Hoffmann-La Roche
🩺 Plain-English Summary (8th-Grade Level)
This study will evaluate the efficacy, safety, and pharmacokinetics of cevostamab in participants with relapsed or refractory multiple myeloma (R/R MM) via intravenous (IV) infusion.
Who can join: Review the eligibility criteria below.
Location: University of Colorado — Aurora, Colorado
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (27 Sites)
Showing the first 25 of 27 sites.
- University of Colorado — Aurora, Colorado
- Mayo Clinic-Jacksonville — Jacksonville, Florida
- University of Maryland Greenebaum Cancer Center — Baltimore, Maryland
- Dana Farber Cancer Institute — Boston, Massachusetts
- Mayo Clinic - Rochester — Rochester, Minnesota
- Icahn School of Medicine at Mount Sinai (ISMMS) — New York, New York
- Memorial Sloan Kettering Cancer Center — New York, New York
- Tennessee Oncology - Nashville — Nashville, Tennessee
- Hunstman Cancer Institute — Salt Lake City, Utah
- Calvary Mater Newcastle — Waratah, New South Wales
- St Vincent's Hospital Melbourne — Fitzroy, Victoria
- UZ Leuven Gasthuisberg — Leuven,
- CHU NANTES - Hôtel Dieu — Nantes,
- APHP - Hospital Saint Louis — Paris,
- CHU de Poitiers - La Miletrie — Poitiers,
- Klinik der Uni zu Köln — Cologne,
- Universitätsklinikum Hamburg-Eppendorf Onkologisches Zentrum Medizinische Klinik II — Hamburg,
- Universitätsklinikum Würzburg — Würzburg,
- Hadassah Ein Karem Hospital — Jerusalem,
- Sheba Medical Center — Ramat Gan,
- Sourasky Medical Centre — Tel Aviv,
- Policlinico S.Orsola-Malpighi — Bologna, Emilia-Romagna
- Asst Papa Giovanni Xxiii — Bergamo, Lombardy
- Fond. IRCCS Istituto Nazionale Tumori — Milan, Lombardy
- A.O. Città della Salute e della Scienza D - Osp. S. Giov. Battista Molinette — Turin, Piedmont
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Multiple Myeloma
- Ixazomib + Pomalidomide + Dexamethasone In MM — Boston, Massachusetts
- A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma — Birmingham, Alabama
- Multiple Myeloma Outcomes Based on Maintenance Therapy Post Autologous Stem Cell Transplant — Tampa, Florida
- MagnetisMM-3: Study Of Elranatamab (PF-06863135) Monotherapy in Participants With Multiple Myeloma Who Are Refractory to at Least One PI, One IMiD and One Anti-CD38 mAb — Beverly Hills, California
- A Study of CLN-619 (Anti-MICA/MICB Antibody) in Patients With Relapsed and Refractory Multiple Myeloma — Phoenix, Arizona
- A Study of Carfilzomib, Lenalidomide, Vorinostat, and Dexamethasone in Relapsed and/or Refractory Multiple Myeloma — Hackensack, New Jersey
Explore by condition: All Multiple Myeloma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.