πŸ›οΈ Verified NIH Record β€’ Updated 2026-01-02

A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers (NCT05544929)

A Phase I, Open-label, Multi-center Study of KFA115 as a Single Agent and in Combination With Pembrolizumab in Patients With Select Advanced Cancers

πŸ”΅ Active, Not Recruiting Phase1 πŸ’Š Investigational Drug / Biologic Sponsor: Novartis Pharmaceuticals

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to characterize the safety and tolerability of KFA115 and KFA115 in combination with pembrolizumab in patients with select advanced cancers, and to identify the maximum tolerated dose and/or recommended dose.

Who can join: Review the eligibility criteria below.

Location: Massachusetts General Hospital . β€” Boston, Massachusetts

Age range: 18 Years to 100 Years

πŸ§ͺ Interventions in This Study

πŸ“‹ "Do I Qualify?" β€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria β†—

πŸ“ All Participating Trial Locations (19 Sites)

  • Massachusetts General Hospital . β€” Boston, Massachusetts
  • Massachusetts General Hospital β€” Boston, Massachusetts
  • NYU School of Medicine β€” New York, New York
  • University of Pittsburgh Medical Center β€” Pittsburgh, Pennsylvania
  • SCRI Oncology Partners β€” Nashville, Tennessee
  • Novartis Investigative Site β€” Toronto, Ontario
  • Novartis Investigative Site β€” Guangzhou, Guangdong
  • Novartis Investigative Site β€” Beijing,
  • Novartis Investigative Site β€” Lyon,
  • Novartis Investigative Site β€” Dresden, Saxony
  • Novartis Investigative Site β€” Essen,
  • Novartis Investigative Site β€” Hong Kong,
  • Novartis Investigative Site β€” Milan, MI
  • Novartis Investigative Site β€” Modena, MO
  • Novartis Investigative Site β€” Chuo Ku, Tokyo
  • Novartis Investigative Site β€” Singapore,
  • Novartis Investigative Site β€” Seoul,
  • Novartis Investigative Site β€” Barcelona, Catalonia
  • Novartis Investigative Site β€” Taipei,

πŸ’° Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA Β§ 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

πŸ’‘ How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
πŸ›οΈ View Official NIH Record β†—