The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure (NCT05545306)
🩺 Plain-English Summary (8th-Grade Level)
Background: Diet-induced thermogenesis (DIT) is the amount of energy one's body uses to eat food, absorb the nutrients from the food, and process those nutrients. Researchers would like to understand more about how changing the balances of protein, fat, carbohydrates, and total calories in the diet can affect DIT. Objective: To learn how different diets can change a person's DIT. Eligibility: Healthy people aged 18 to 60 years who have not intentionally lost weight in the past 6 months. Design: Participants will stay in a clinic for about 35 days. They will eat only the food provided. They will receive 8 different diets during the study, including 7 test diets. Participants will undergo multiple tests. They will be screened with blood and urine tests and a test of their heart function. During the first few days: Their waist, thigh, and neck circumference will be measured. They will have a DXA scan: They will lie on a padded table for about 20 minutes while an instrument measures the amount of fat in their body. They will be tested for diabetes. They will answer questionnaires about topics including eating behavior, hunger, and stress. Throughout the study: Their weight will be measured daily. Blood tests will be repeated. They will stay in a metabolic chamber a total of 9 times. They will remain in a closed room for 24 hours while researchers monitor the room temperature and levels of oxygen and carbon dioxide. Participants will collect all their urine for each 24-hour period. ...
Who can join: Review the eligibility criteria below.
Location: NIDDK, Phoenix — Phoenix, Arizona
Age range: 18 Years to 60 Years
🧪 Interventions in This Study
- +200% of dietary requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat (DIETARY_SUPPLEMENT)
- fasting (DIETARY_SUPPLEMENT)
- -50% of energy balance requirements. 50% of calories from carbohydrates, 20% from protein, and 30% from fat (DIETARY_SUPPLEMENT)
- +150% of energy balance requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat (DIETARY_SUPPLEMENT)
- +200% of dietary requirements, 51% of the calories from carbohydrates, 46%, from fat and 3% from protein (DIETARY_SUPPLEMENT)
- -25% of energy balance requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat (DIETARY_SUPPLEMENT)
- +150% of dietary requirements, 51% of the calories from carbohydrates, 46%, from fat and 3% from protein (DIETARY_SUPPLEMENT)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- NIDDK, Phoenix — Phoenix, Arizona
📞 Contact the Study Coordinator
Phone: (602) 200-5315
Email: niddkphxcontact@mail.nih.gov
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.