๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-03-30

A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2) (NCT05552976)

A Phase 3, Two-stage, Randomized, Multicenter, Open-label Study Comparing Mezigdomide (CC-92480/BMS-986348), Carfilzomib, and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM): SUCCESSOR-2

๐Ÿ”ต Active, Not Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Bristol-Myers Squibb

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The purpose of the study is to compare Mezigdomide (CC-92480/BMS-986348) with carfilzomib and dexamethasone (MeziKD) against carfilzomib and dexamethasone (Kd) in the treatment of RRMM: SUCCESSOR-2.

Who can join: Review the eligibility criteria below.

Location: Local Institution - 0046 โ€” Mobile, Alabama

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (207 Sites)

Showing the first 25 of 207 sites.

  • Local Institution - 0046 โ€” Mobile, Alabama
  • Local Institution - 0005 โ€” Cerritos, California
  • Local Institution - 0190 โ€” Irvine, California
  • Local Institution - 0187 โ€” Los Angeles, California
  • Local Institution - 0344 โ€” Santa Rosa, California
  • Local Institution - 0339 โ€” Stockton, California
  • Local Institution - 0279 โ€” Newark, Delaware
  • Local Institution - 0341 โ€” Fort Myers, Florida
  • Local Institution - 0342 โ€” St. Petersburg, Florida
  • Local Institution - 0340 โ€” West Palm Beach, Florida
  • Local Institution - 0348 โ€” Atlanta, Georgia
  • Local Institution - 0291 โ€” Atlanta, Georgia
  • Saint Alphonsus Regional Medical Center โ€” Boise, Idaho
  • Local Institution - 0289 โ€” Annapolis, Maryland
  • Local Institution - 0204 โ€” Boston, Massachusetts
  • Local Institution - 0346 โ€” Minneapolis, Minnesota
  • Local Institution - 0222 โ€” Little Silver, New Jersey
  • Local Institution - 0199 โ€” The Bronx, New York
  • Local Institution - 0322 โ€” Cleveland, Ohio
  • Local Institution - 0172 โ€” Columbus, Ohio
  • Local Institution - 0321 โ€” Providence, Rhode Island
  • Local Institution - 0338 โ€” Greer, South Carolina
  • Local Institution - 0349 โ€” Chattanooga, Tennessee
  • Local Institution - 0323 โ€” Nashville, Tennessee
  • Local Institution - 0337 โ€” Fort Worth, Texas

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—