A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight (NCT05567796)
Efficacy and Safety of Cagrilintide s.c. 2.4 Milligram (mg) in Combination With Semaglutide Subcutaneous (s.c). 2.4 mg (CagriSema s.c. 2.4 mg/2.4 mg) Once-weekly in Participants With Overweight or Obesity
🩺 Plain-English Summary (8th-Grade Level)
This study has 2 parts: First part is the main study and second part is the extension study. During the main study participants will receive 1 of 4 study medicines. If participants continue in the extension study, they will not receive any study medicine during the extension. The main study will look at how well CagriSema helps participants with excess body weight lose weight compared to a "dummy" medicine and 2 other medicines, cagrilintide and semaglutide. Participants will either get CagriSema, cagrilintide,semaglutide or "dummy" medicine. Which treatment participants get is decided by chance. They will take one injection once a week. The study medicine is injected briefly with a thin needle, typically in the stomach, thighs or upper arms. Extension study: After the main study, not all participants will continue in the extension study. The study staff will tell the participant if they will continue or not into the extension study. In the extension study we will look at what happens to the participant's body weight and diseases related to excess body weight after the participant stops taking the study medicine. The main study will last for about 1½ years and the extension study will last for another 2 years.
Who can join: Review the eligibility criteria below.
Location: Univ of Alabama Birmingham — Birmingham, Alabama
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (256 Sites)
Showing the first 25 of 256 sites.
- Univ of Alabama Birmingham — Birmingham, Alabama
- Velocity Clin Res Los Angeles — Los Angeles, California
- Velocity Clin Res Wstlke — Los Angeles, California
- Univ of Colorado at Denver — Aurora, Colorado
- OptumCare Clinical Trials LLC — Golden, Colorado
- Northeast Research Institute — Fleming Island, Florida
- South Broward Research LLC — Miramar, Florida
- Clinical Neuroscience Solution — Orlando, Florida
- Florida Inst For Clin Res — Orlando, Florida
- Florida Institute for Clinical research — Orlando, Florida
- Clinical Trial Res Assoc,Inc — Plantation, Florida
- Hope Clin Res & Wellness — Conyers, Georgia
- East West Med Res Inst — Honolulu, Hawaii
- Great Lakes Clinical Trials — Chicago, Illinois
- Endeavor Health — Skokie, Illinois
- Evanston Premier Hlthcr Res — Skokie, Illinois
- Midwest Inst For Clin Res — Indianapolis, Indiana
- Northern Pines Hlth Ctr, PC — Buckley, Michigan
- StudyMetrix Research LLC — City of Saint Peters, Missouri
- Velocity Clinical Research Binghamton — Binghamton, New York
- Comprehensive Weight Ctrl Prog — New York, New York
- University of North Carolina — Chapel Hill, North Carolina
- University of North Carolina — Chapel Hill, North Carolina
- Medication Mgmnt, LLC_Grnsboro — Greensboro, North Carolina
- PharmQuest Life Sciences LLC — Greensboro, North Carolina
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.