Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial (NCT05581303)
A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Olpasiran on Major Cardiovascular Events in Participants With Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein(a)
🩺 Plain-English Summary (8th-Grade Level)
The primary objective of this trial is to compare the effect of treatment with olpasiran, to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants with atherosclerotic cardiovascular disease (ASCVD) and elevated Lipoprotein(a).
Who can join: Review the eligibility criteria below.
Location: Ascension Saint Vincents Birmingham — Birmingham, Alabama
Age range: 18 Years to 85 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (737 Sites)
Showing the first 25 of 737 sites.
- Ascension Saint Vincents Birmingham — Birmingham, Alabama
- Grandview Medical Center Affinity Cardiovascular Specialists, LLC — Birmingham, Alabama
- Heart Center Research LLC — Huntsville, Alabama
- Mobile Heart Specialists PC — Mobile, Alabama
- Alaska Cardiovascular Research Foundation — Anchorage, Alaska
- Elite Clinical Studies LLC — Phoenix, Arizona
- HonorHealth Research and Innovation Institute — Scottsdale, Arizona
- National Heart Institute — Beverly Hills, California
- Vitality Clinical Research — Beverly Hills, California
- University of California San Diego — La Jolla, California
- VA Greater Los Angeles Healthcare System — Los Angeles, California
- University of California Irvine — Orange, California
- University of California Los Angeles — Santa Monica, California
- Manshadi Heart Institute — Stockton, California
- Med Partners, Inc dba Premiere Medical Center, Inc — Toluca Lake, California
- UCHealth Memorial Central — Colorado Springs, Colorado
- Cardiology Associates of Fairfield County PC — Stamford, Connecticut
- MedStar Clinical Research — Washington D.C., District of Columbia
- Excel Medical Clinical Trials — Boca Raton, Florida
- Bay Area Cardiology — Brandon, Florida
- Clearwater Cardiovascular Consultants — Clearwater, Florida
- Cardiology Associates Research LLC — Daytona Beach, Florida
- Jellinger and Lerman MD PA dba The Center for Diabetes and Endocrine Care — Fort Lauderdale, Florida
- Elite Cardiac Research Center LLC — Hialeah, Florida
- East Coast Institute for Research, LLC — Jacksonville, Florida
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Atherosclerotic Cardiovascular Disease
- Cardiovascular Outcome Study to Evaluate the Effect of Obicetrapib in Patients With Cardiovascular Disease — Alexander City, Alabama
- A Randomized Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Cardiovascular Disease — Boston, Massachusetts
- VictORION-INCLUSION: Evaluating Inclisiran for Cholesterol Managment in Heart Disease — Birmingham, Alabama
- Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease — Birmingham, Alabama
- Clinical Assessment and Targeted Imaging to Characterize High-Risk Atherosclerotic Cardiovascular Disease of Survivors in SJLIFE — Memphis, Tennessee
Explore by condition: All Atherosclerotic Cardiovascular Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.