Phase 2b Study of GSK4532990 in Adults With NASH (NCT05583344)
17 ฮฒ-Hydroxysteroid Dehydrogenase Type 13 Minimization for the Treatment of NASH (HORIZON): A Double-Blind, Placebo-Controlled Phase 2b Study to Evaluate the Efficacy and Safety of GSK4532990 in Adults With Nonalcoholic Steatohepatitis
๐ฉบ Plain-English Summary (8th-Grade Level)
The purpose of this study is to measure improvements in liver fibrosis and inflammation with GSK4532990 compared with placebo in participants with NASH and advanced fibrosis on biopsy (F3 or F4). The study duration will be up to 76 weeks including the screening period. The treatment duration will be up to 52 weeks.
Who can join: Review the eligibility criteria below.
Location: GSK Investigational Site โ Homewood, Alabama
Age range: 18 Years to 75 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (170 Sites)
Showing the first 25 of 170 sites.
- GSK Investigational Site โ Homewood, Alabama
- GSK Investigational Site โ Chandler, Arizona
- GSK Investigational Site โ Chandler, Arizona
- GSK Investigational Site โ Mesa, Arizona
- GSK Investigational Site โ Jonesboro, Arkansas
- GSK Investigational Site โ North Little Rock, Arkansas
- GSK Investigational Site โ Huntington Park, California
- GSK Investigational Site โ La Jolla, California
- GSK Investigational Site โ Orange, California
- GSK Investigational Site โ Poway, California
- GSK Investigational Site โ Rialto, California
- GSK Investigational Site โ Sacramento, California
- GSK Investigational Site โ San Francisco, California
- GSK Investigational Site โ Santa Ana, California
- GSK Investigational Site โ Van Nuys, California
- GSK Investigational Site โ Colorado Springs, Colorado
- GSK Investigational Site โ Bradenton, Florida
- GSK Investigational Site โ Coral Gables, Florida
- GSK Investigational Site โ Fort Myers, Florida
- GSK Investigational Site โ Hallandale, Florida
- GSK Investigational Site โ Hialeah, Florida
- GSK Investigational Site โ Homestead, Florida
- GSK Investigational Site โ Jupiter, Florida
- GSK Investigational Site โ Lakewood Rch, Florida
- GSK Investigational Site โ Miami, Florida
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Effectiveness of Endoscopic Sleeve Gastroplasty in Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis โ Morgantown, West Virginia
Explore by condition: All Nonalcoholic Fatty Liver Disease clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.