Decolonization to Reduce After-Surgery Events of Surgical Site Infection (NCT05586776)
🩺 Plain-English Summary (8th-Grade Level)
The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection) is a two-arm multi-center individual placebo-controlled randomized (2,700 participants randomized 1:1) clinical trial to reduce post-discharge surgical site infection following open colon or small bowel surgery by comparing chlorhexidine bathing plus nasal mupirocin in the 30 days following discharge to soap without antiseptic properties (placebo) and placebo nasal ointment. This trial seeks to enhance the care of the 675,000 patients annually who undergo colon and small bowel surgery by finding simple and efficacious interventions to reduce SSI.
Who can join: Review the eligibility criteria below.
Location: Hoag Memorial Hospital Presbyterian — Newport Beach, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (4 Sites)
- Hoag Memorial Hospital Presbyterian — Newport Beach, California
- University of California, Irvine Medical Center — Orange, California
- University of California, Davis Medical Center — Sacramento, California
- University of California, San Francisco Medical Center — San Francisco, California
📞 Contact the Study Coordinator
Phone: (949) 824-5073
Email: sshuang@hs.uci.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Surgical Site Infection
- Utility of Single-dose Oral Antibiotic Prophylaxis in Prevention of Surgical Site Infection in Dermatologic Surgery — Roanoke, Virginia
- Neutrophil Phenotypic Profiling and Surgical Site Infections in Surgical Patients — Boston, Massachusetts
- PVI to Prevent S. Aureus SSI After Fixation of HELEF (POTENT Study) — Atlanta, Georgia
- A Stratified, Multi-ARm, muLti-site Randomised Platform Trial Aiming to Reduce the INcidence of Post-operative SSI — Abomey-Calavi,
- PRevention Of Trauma-related Infections Through an Embedded Clinical Trials Network — Houston, Texas
- A Novel Surgical Irrigation Solution in Post-Mastectomy Reconstruction: Evaluating Xperience™ — Chapel Hill, North Carolina
Explore by condition: All Surgical Site Infection clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.