๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-05-19

A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (NCT05595642)

A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Astegolimab in Patients With Chronic Obstructive Pulmonary Disease

๐Ÿ”ต Active, Not Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Hoffmann-La Roche

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This study will evaluate the efficacy and safety of astegolimab compared with placebo in participants with chronic obstructive pulmonary disease (COPD) who are former or current smokers and have a history of frequent exacerbations.

Who can join: Review the eligibility criteria below.

Location: University of Alabama at Birmingham โ€” Birmingham, Alabama

Age range: 40 Years to 80 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (382 Sites)

Showing the first 25 of 382 sites.

  • University of Alabama at Birmingham โ€” Birmingham, Alabama
  • SEC Clinical Research LLC - Dothan 2 - ClinEdge - PPDS โ€” Dothan, Alabama
  • Pulmonary Associates PA โ€” Glendale, Arizona
  • AES - DRS - Synexus Clinical Research US, Inc. - Tucson โ€” Tucson, Arizona
  • Kern Research โ€” Bakersfield, California
  • Allergy & Asthma Medical Group of the Bay Area โ€” Walnut Creek, California
  • Finlay Medical Research Corporation โ€” Greenacres City, Florida
  • San Marcus Research Clinic Inc. โ€” Miami, Florida
  • Oceane7 Medical & Research Center, Inc. โ€” Miami, Florida
  • Avantis Clinical Research, LLC โ€” Miami, Florida
  • Research Institute of South Florida Inc โ€” Miami, Florida
  • Diverse Clinical Research, LLC โ€” Miami, Florida
  • Central Florida Pulmonary Group, PA โ€” Orlando, Florida
  • AES - DRS - Synexus Clinical Research US, Inc. - The Villages โ€” The Villages, Florida
  • AES - DRS - Synexus Clinical Research US, Inc. - Atlanta โ€” Atlanta, Georgia
  • Allergy Center at Brookstone Research - Centricity Research - HyperCore - PPD โ€” Columbus, Georgia
  • Pivotal Research Solutions โ€” Stonecrest, Georgia
  • ASHA Clinical Research - ClinEdge - PPDS โ€” Hammond, Indiana
  • The Research Group of Lexington, LLC โ€” Lexington, Kentucky
  • Best Clinical Trials โ€” New Orleans, Louisiana
  • Paul A. Shapero, MD, PA โ€” Bangor, Maine
  • Pulmonary Research Institute of Southeast Michigan โ€” Farmington Hills, Michigan
  • Flushing Road Internal Medicine and Pediatrics - F โ€” Flint, Michigan
  • Revive Research Institute โ€” Lathrup Village, Michigan
  • Oakland Medical Research Center โ€” Troy, Michigan

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—