🏛️ Verified NIH Record • Updated 2025-07-03
Effect of Hormones on Frequency of Headache and Brain Structure and Function in Puberty (NCT05607303)
🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: University of Colorado, Denver
🩺 Plain-English Summary (8th-Grade Level)
With a rising population of transgender adults and youth, there is a need for more research to meet the needs of this community. Transfemale (MTF) youth (male sex, female gender identity) who begin clinical Gender Affirming Hormone Therapy (GAHT) with estrogen may be at a higher risk for headache since estrogen has been linked to headache in cisgender females (female sex, female gender identity). This research hopes to learn more about headache in MTF youth.
Who can join: Review the eligibility criteria below.
Location: Children's Hospital Colorado — Aurora, Colorado
Age range: 9 Years to 20 Years
🧪 Interventions in This Study
- Clinical estrogen therapy (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Children's Hospital Colorado — Aurora, Colorado
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Headache
- 0.5% Bupivacaine Lower Cervical Intramuscular Injection vs IV Medications for Headache Treatment — Gainesville, Florida
- The Effect of Osteopathic Treatment on Craniocervico-Mandibular Dysfunction — Auburn, Alabama
- Mind Body Balance for Pediatric Migraine — Aurora, Colorado
- Responding With Evidence and Access for Childhood Headaches — Birmingham, Alabama
Explore by condition: All Headache clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.