🏛️ Verified NIH Record • Updated 2026-06-08
A Clinical Trial of Tolcapone in Obsessive Compulsive Disorder (NCT05624528)
A Double-Blind, Randomized, Placebo-Controlled Study of Tolcapone for OCD
🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: University of Chicago
🩺 Plain-English Summary (8th-Grade Level)
The primary aim of the present study is to examine the efficacy and safety of tolcapone in adults with moderate to severe OCD.
Who can join: Review the eligibility criteria below.
Location: University of Chicago Medical Center — Chicago, Illinois
Age range: 18 Years to 65 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- University of Chicago Medical Center — Chicago, Illinois
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Obsessive-Compulsive Disorder
- Feasibility, Clinical Effects, and Safety of Psilocybin-assisted Psychotherapy for Treatment-resistant OCD — Toronto, Ontario
- Effects of Psilocybin in Obsessive Compulsive Disorder — Baltimore, Maryland
- Development of Adaptive Deep Brain Stimulation for OCD — Pittsburgh, Pennsylvania
- Phase II Adaptive Deep Brain Stimulation for Obsessive-Compulsive Disorder — Pittsburgh, Pennsylvania
- Personalized DBS for OCD Guided by Stereoencephalography Mapping — San Francisco, California
- Brain Recordings in Patients Undergoing Deep Brain Stimulation (DBS) for Severe Obsessive-Compulsive Disorder (OCD) — Houston, Texas
Explore by condition: All Obsessive-Compulsive Disorder clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.