A Study to Assess Safety, Tolerability, and Pharmacokinetics of ABSK121-NX in Patients With Advanced Solid Tumors (NCT05627063)
A Phase 1, Open-Label Study of ABSK121-NX to Assess Safety, Tolerability, and Pharmacokinetics in Patients With Advanced Solid Tumors
๐ฉบ Plain-English Summary (8th-Grade Level)
This is an open-label phase 1 study with expansion. The study will start with a dose escalation of single-agent ABSK121-NX administered in repeated 28-day cycles in patients with advanced solid tumors to evaluate safety and tolerability. The expansion part will investigate oral ABSK121-NX at the recommended dose for expansion (RDE) to further evaluate safety and tolerability among selected tumor types. Preliminary antitumor activity will also be assessed.
Who can join: Review the eligibility criteria below.
Location: UC San Diego Moores Cancer Center โ La Jolla, California
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (24 Sites)
- UC San Diego Moores Cancer Center โ La Jolla, California
- Karmanos Cancer Institute โ Detroit, Michigan
- Comprehensive Cancer Centers of Nevada โ Las Vegas, Nevada
- Gabrail Cancer Center Research โ Canton, Ohio
- Chongqing University Cancer Hospital โ Chongqing, Chongqing Municipality
- The First Affiliated Hospital of Henan University of Science & Technology โ Luoyang, Henan
- The First Affiliated Hospital of Zhengzhou University โ Zhengzhou, Henan
- Hubei Cancer Hospital โ Wuhan, Hubei
- Hunan Central Hospital โ Changsha, Hunan
- The Affiliated Hospital of Inner Mongolia Medical University โ Hohhot, Inner Mongolia
- The First Affiliated Hospital of Nanchang University โ Nanchang, Jiangxi
- Jilin Cancer Hospital โ Changchun, Jilin
- The First Hospital of China Medical University โ Shenyang, Liaoning
- Shanghai East Hospital Tongji University โ Shanghai, Shanghai Municipality
- Shanxi Provincial Cancer Hospital โ Taiyuan, Shanxi
- West China School of Medicine/West China Hospital of Sichuan University โ Chengdu, Sichuan
- Mianyang Central Hospital โ Mianyang, Sichuan
- Zhejiang University Cancer Hospital โ Hangzhou, Zhejiang
- Fujian Cancer Hospital (Department of Hepatobiliary and Pancreatic Oncology /Phase I Ward) โ Fuzhou,
- Harbin Medical University Cancer Hospital (Gastroenterology Department 2nd Ward) โ Haerbin,
- Zhongshan Hospital of Fudan University (Hepatological Surgery Department) โ Shanghai,
- Zhongshan Hospital of Fudan University (Medical Oncology Department) โ Shanghai,
- Liaoning Cancer Hospital (Phase I Ward) โ Shenyang,
- Yantai Yuhuangding Hospital (Department of Medical Oncology, 1) โ Yantai,
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Study of PD1 Blockade by Pembrolizumab With Stereotactic Body Radiotherapy in Advanced Solid Tumors โ Chicago, Illinois
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๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.