๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2025-10-16

A Study to Assess Safety, Tolerability, and Pharmacokinetics of ABSK121-NX in Patients With Advanced Solid Tumors (NCT05627063)

A Phase 1, Open-Label Study of ABSK121-NX to Assess Safety, Tolerability, and Pharmacokinetics in Patients With Advanced Solid Tumors

๐Ÿ”ต Active, Not Recruiting Phase1 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Abbisko Therapeutics Co, Ltd

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This is an open-label phase 1 study with expansion. The study will start with a dose escalation of single-agent ABSK121-NX administered in repeated 28-day cycles in patients with advanced solid tumors to evaluate safety and tolerability. The expansion part will investigate oral ABSK121-NX at the recommended dose for expansion (RDE) to further evaluate safety and tolerability among selected tumor types. Preliminary antitumor activity will also be assessed.

Who can join: Review the eligibility criteria below.

Location: UC San Diego Moores Cancer Center โ€” La Jolla, California

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (24 Sites)

  • UC San Diego Moores Cancer Center โ€” La Jolla, California
  • Karmanos Cancer Institute โ€” Detroit, Michigan
  • Comprehensive Cancer Centers of Nevada โ€” Las Vegas, Nevada
  • Gabrail Cancer Center Research โ€” Canton, Ohio
  • Chongqing University Cancer Hospital โ€” Chongqing, Chongqing Municipality
  • The First Affiliated Hospital of Henan University of Science & Technology โ€” Luoyang, Henan
  • The First Affiliated Hospital of Zhengzhou University โ€” Zhengzhou, Henan
  • Hubei Cancer Hospital โ€” Wuhan, Hubei
  • Hunan Central Hospital โ€” Changsha, Hunan
  • The Affiliated Hospital of Inner Mongolia Medical University โ€” Hohhot, Inner Mongolia
  • The First Affiliated Hospital of Nanchang University โ€” Nanchang, Jiangxi
  • Jilin Cancer Hospital โ€” Changchun, Jilin
  • The First Hospital of China Medical University โ€” Shenyang, Liaoning
  • Shanghai East Hospital Tongji University โ€” Shanghai, Shanghai Municipality
  • Shanxi Provincial Cancer Hospital โ€” Taiyuan, Shanxi
  • West China School of Medicine/West China Hospital of Sichuan University โ€” Chengdu, Sichuan
  • Mianyang Central Hospital โ€” Mianyang, Sichuan
  • Zhejiang University Cancer Hospital โ€” Hangzhou, Zhejiang
  • Fujian Cancer Hospital (Department of Hepatobiliary and Pancreatic Oncology /Phase I Ward) โ€” Fuzhou,
  • Harbin Medical University Cancer Hospital (Gastroenterology Department 2nd Ward) โ€” Haerbin,
  • Zhongshan Hospital of Fudan University (Hepatological Surgery Department) โ€” Shanghai,
  • Zhongshan Hospital of Fudan University (Medical Oncology Department) โ€” Shanghai,
  • Liaoning Cancer Hospital (Phase I Ward) โ€” Shenyang,
  • Yantai Yuhuangding Hospital (Department of Medical Oncology, 1) โ€” Yantai,

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Solid Tumor clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—