A Study of Dato-DXd With or Without Durvalumab Versus Investigator's Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Without Pathological Complete Response Following Neoadjuvant Therapy (TROPION-Breast03) (NCT05629585)
A Phase 3 Open-label, Randomised Study of Datopotamab Deruxtecan (DatoDXd) With or Without Durvalumab Versus Investigator's Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Who Have Residual Invasive Disease in the Breast and/or Axillary Lymph Nodes at Surgical Resection Following Neoadjuvant Systemic Therapy (TROPION-Breast03)
🩺 Plain-English Summary (8th-Grade Level)
This is a Phase III, randomized, open-label, 3-arm, multicenter, international study assessing the efficacy and safety of Dato-DXd with or without durvalumab compared with ICT in participants with stage I to III TNBC with residual invasive disease in the breast and/or axillary lymph nodes at surgical resection following neoadjuvant systemic therapy.
Who can join: Review the eligibility criteria below.
Location: Research Site — Gilbert, Arizona
Age range: 18 Years to 130 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (276 Sites)
Showing the first 25 of 276 sites.
- Research Site — Gilbert, Arizona
- Research Site — Tucson, Arizona
- Research Site — Tucson, Arizona
- Research Site — Hot Springs, Arkansas
- Research Site — Little Rock, Arkansas
- Research Site — Springdale, Arkansas
- Research Site — Beverly Hills, California
- Research Site — Costa Mesa, California
- Research Site — Duarte, California
- Research Site — Fountain Valley, California
- Research Site — Irvine, California
- Research Site — La Jolla, California
- Research Site — Lakewood, California
- Research Site — Los Angeles, California
- Research Site — Los Angeles, California
- Research Site — Newport Beach, California
- Research Site — Newport Beach, California
- Research Site — Orange, California
- Research Site — Roseville, California
- Research Site — Upland, California
- Research Site — Vallejo, California
- Research Site — Denver, Colorado
- Research Site — New Haven, Connecticut
- Research Site — Newark, Delaware
- Research Site — Washington D.C., District of Columbia
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.