Repurposing Dupilumab for Management of Pruritic Genetic Inflammatory Skin Disorders (NCT05649098)
Repurposing Dupilumab for Management of Pruritic Genetic Inflammatory Skin Disorders: a Single-Site Pilot Study
🩺 Plain-English Summary (8th-Grade Level)
Severe itch is a common symptom of many genetic skin disorders and leads to a negative impact on patient quality of life. The investigators hypothesize that: a) intervention with dupilumab will improve itch in patients with pruritic genetic inflammatory skin disorders, even those not recognized to be Th2-driven; and b) the administration of dupilumab will be well-tolerated, regardless of underlying genetic skin disorder. The total clinical study duration will be 26 months (104 Weeks). The treatment period will include a 16-week open-label phase and a 20-month long-term extension phase for those who qualify and wish to continue.
Who can join: Review the eligibility criteria below.
Location: Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois
Age range: 6 Months
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois
📞 Contact the Study Coordinator
Phone: (312) 227-6817
Email: NUderm-research@northwestern.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Skin Diseases
- Trem-1 and Ultraviolet Radiation-induced Immune Suppression — Birmingham, Alabama
- Driving Time and Facial Skin Hydration Asymmetry in Florida Drivers — Orlando, Florida
Explore by condition: All Skin Diseases clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.