🏛️ Verified NIH Record • Updated 2026-06-05
The CALERIE™ Legacy Study (NCT05651620)
Legacy Effects of CALERIE™, a 2-year Calorie Restriction Intervention, on Hallmarks of Healthspan and Aging
🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: Tufts University
🩺 Plain-English Summary (8th-Grade Level)
The purpose of the CALERIE Legacy Study is to follow up on the health and wellness of participants from phase 2 of the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial, which was conducted from 2007 to 2011.
Who can join: Review the eligibility criteria below.
Location: Pennington Biomedical Research Center — Baton Rouge, Louisiana
Age range: 33 Years to 70 Years
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (3 Sites)
- Pennington Biomedical Research Center — Baton Rouge, Louisiana
- Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University — Boston, Massachusetts
- Washington University School of Medicine — St Louis, Missouri
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Calorie Restriction clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.