Nicotinamide and Pyruvate for Open Angle Glaucoma: A Randomized Clinical Study (NCT05695027)
🩺 Plain-English Summary (8th-Grade Level)
The objective of this study is to determine if a combination of oral nicotinamide and pyruvate (N\&P) can maintain eye health as compared to placebo while standard-of-care intraocular pressure-lowering glaucoma medications are used to treat glaucoma. A total of up to 188 participants will be enrolled and randomized 1:1 to receive N\&P or placebo for 87 weeks (20 months). Participants will be followed for a total of 91 weeks (21 months).
Who can join: Review the eligibility criteria below.
Location: Stanford University Department of Ophthalmology — Palo Alto, California
Age range: 35 Years to 85 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (3 Sites)
- Stanford University Department of Ophthalmology — Palo Alto, California
- ColumbiaDoctors Ophthalmology - 880 Third Avenue — New York, New York
- Columbia University Irving Medical Center - 622 W 168th St — New York, New York
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Primary Open Angle Glaucoma
- A Study of the Helix Surgical System in Primary Open-Angle Glaucoma (POAG) and Cataract (HELIX) — Panama City,
- Advanced Glaucoma Progression Study — Los Angeles, California
- Rocklatan Adds Pressure Reduction After MIGS (Minimally Invasive Glaucoma Surgery) — Las Vegas, Nevada
- A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma — Glendale, Arizona
- Hydrus® Microstent New Enrollment Post-Approval Study — Irvine, California
Explore by condition: All Primary Open Angle Glaucoma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.