Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease (NCT05701358)
A Randomized Trial of Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization Strategies & an Observational Study of Optical Coherence Tomography in Patients With Acute MI & Multivessel Coronary Artery Disease
🩺 Plain-English Summary (8th-Grade Level)
COMPLETE-2 is a prospective, multi-centre, randomized controlled trial comparing a strategy of physiology-guided complete revascularization to angiography-guided complete revascularization in patients with acute ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel coronary artery disease (CAD) who have undergone successful culprit lesion Percutaneous Coronary Intervention (PCI). COMPLETE-2 OCT is a large scale, prospective, multi-centre, observational, imaging study of patients with STEMI or NSTEMI and multivessel CAD in a subset of eligible COMPLETE-2 patients.
Who can join: Review the eligibility criteria below.
Location: UCLA — Los Angeles, California
Age range: 18 Years
🧪 Interventions in This Study
- Physiology-guided NCL PCI (PROCEDURE)
- Angiography-guided NCL PCI (PROCEDURE)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (113 Sites)
Showing the first 25 of 113 sites.
- UCLA — Los Angeles, California
- University of California, San Francisco — San Francisco, California
- Cardiovascular Research Institute of Kansas — Wichita, Kansas
- The Johns Hopkins University School of Medicine — Baltimore, Maryland
- University of Michigan — Ann Arbor, Michigan
- Metropolitan Cardiology Consultants / Metropolitan Heart and Vascular Institute (MCC/MHVI) — Coon Rapids, Minnesota
- RWJ Barnabas Health — Jersey City, New Jersey
- Bassett Medical Center — Cooperstown, New York
- VA New York Harbor HealthCare System — New York, New York
- NYU Grossman School of Medicine — New York, New York
- Montefiore Medical Center — The Bronx, New York
- Cleveland Clinic — Cleveland, Ohio
- University of Virginia Medical Center — Charlottesville, Virginia
- Westmead Hospital — Westmead, New South Wales
- Klinik Floridsdorf — Vienna,
- McGill University Health Centre (MUHC) — Montreal, Quebec
- William Osler Health System — Brampton,
- University of Alberta Hospital, Mazankowski Heart — Edmonton,
- Hamilton Health Sciences — Hamilton,
- Kingston Health Sciences Centre — Kingston,
- St. Mary's General Hospital — Kitchener,
- London Health Sciences Centre — London,
- Centre Hospitalier de l'Universite de Montreal — Montreal,
- Hopital du Sacre-Coeur de Montreal — Montreal,
- Southlake Regional Health Centre — Newmarket,
📞 Contact the Study Coordinator
Phone: (905) 521-2100
Email: complete-2@phri.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.