DEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombosis (NCT05701917)
DEFIANCE - ClotTriever® Thrombectomy System vs. Anticoagulation Alone for Treatment of Deep Vein Thrombosis
🩺 Plain-English Summary (8th-Grade Level)
This study is a prospective, multicenter, randomized controlled trial of an interventional strategy using the ClotTriever System to achieve and maintain vessel patency (ClotTriever Intervention Arm) versus conservative medical management using anticoagulation therapy alone (Conservative Medical Management Arm) in the treatment of subjects with symptomatic unilateral iliofemoral DVT. The study will collect data on demographics, comorbidities, details from the DVT diagnosis and treatment, and clinical outcomes through the 6-month follow up visit.
Who can join: Review the eligibility criteria below.
Location: Honor Health — Scottsdale, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (64 Sites)
Showing the first 25 of 64 sites.
- Honor Health — Scottsdale, Arizona
- Pima Heart and Vascular — Tucson, Arizona
- UCI Medical Center — Orange, California
- Vascular and Interventional Specialists of Orange County — Orange, California
- Huntington Health — Pasadena, California
- University Of Colorado — Denver, Colorado
- Yale University — New Haven, Connecticut
- MedStar Health Research Institution — Washington D.C., District of Columbia
- Manatee Memorial Hospital — Bradenton, Florida
- Baptist Health Research Institute — Jacksonville, Florida
- Lakeland Vascular Institute — Lakeland, Florida
- HCA Florida Largo Hospital — Largo, Florida
- Sarasota Memorial Hospital — Sarasota, Florida
- BayCare Health System — Tampa, Florida
- Memorial Health University Medical Center — Savannah, Georgia
- Community Healthcare System — Munster, Indiana
- St. Elizabeth Edgewood — Edgewood, Kentucky
- University of Maryland — Baltimore, Maryland
- McLaren Healthcare — Bay City, Michigan
- Henry Ford Health — Detroit, Michigan
- MyMichigan Medical Center — Midland, Michigan
- University of Missouri — Columbia, Missouri
- Saint Luke's Hospital of Kansas City — Kansas City, Missouri
- St. Louis University — St Louis, Missouri
- University Medical Center of Southern Nevada — Las Vegas, Nevada
📞 Contact the Study Coordinator
Phone: (949) 466-9458
Email: mark.sung@stryker.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.