A Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination Treatments (NCT05714839)
A Phase 1/2 Open-label, Multicentre, Dose Escalation and Expansion Study to Investigate the Safety, Tolerability, and Clinical Activity of Belantamab as Monotherapy and in Combination With Other Treatments in Participants With Multiple Myeloma
🩺 Plain-English Summary (8th-Grade Level)
The study consists of three parts: * Part 1: The primary purpose of this part aims to evaluate the safety, tolerability, and clinical activity of escalating doses of single agent belantamab in participants with refractory multiple myeloma (RRMM) who have received at least 3 prior therapies (4L+). * Part 2: The primary purpose of this part is to evaluate the safety, tolerability, and clinical activity of different doses of belantamab in combination with a fixed dose of Belantamab mafodotin (delivered as separate drugs) in participants with RRMM who have received at least 3 prior therapies (4L+). * Part 3: The Primary purpose of this part will evaluate the clinical activity of a selected dose of the belantamab in combination with the pomalidomide-dexamethasone (Pd) standard of care (SoC) backbone. The study will focus on participants with multiple myeloma who have undergone at least one prior line of therapy, including treatment with lenalidomide.
Who can join: Review the eligibility criteria below.
Location: GSK Investigational Site — Bullhead City, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (44 Sites)
Showing the first 25 of 44 sites.
- GSK Investigational Site — Bullhead City, Arizona
- GSK Investigational Site — Los Angeles, California
- GSK Investigational Site — Pembroke Pines, Florida
- GSK Investigational Site — Boston, Massachusetts
- GSK Investigational Site — Grand Rapids, Michigan
- GSK Investigational Site — Chapel Hill, North Carolina
- GSK Investigational Site — Wilson, North Carolina
- GSK Investigational Site — Canton, Ohio
- GSK Investigational Site — Chattanooga, Tennessee
- GSK Investigational Site — Nashville, Tennessee
- GSK Investigational Site — Fort Worth, Texas
- GSK Investigational Site — Capital Federal,
- GSK Investigational Site — Ciudadela,
- GSK Investigational Site — Rosario,
- GSK Investigational Site — San Juan Bautista,
- GSK Investigational Site — Viedma,
- GSK Investigational Site — Fitzroy, Victoria
- GSK Investigational Site — Nedlands, Western Australia
- GSK Investigational Site — Joinville,
- GSK Investigational Site — Salvador,
- GSK Investigational Site — São Paulo,
- GSK Investigational Site — Suzhou,
- GSK Investigational Site — Beersheba,
- GSK Investigational Site — Jerusalem,
- GSK Investigational Site — Ramat Gan,
📞 Contact the Study Coordinator
Phone: (877) 379-3718
Email: GSKClinicalSupportHD@gsk.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Multiple Myeloma
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- Multiple Myeloma Outcomes Based on Maintenance Therapy Post Autologous Stem Cell Transplant — Tampa, Florida
- MagnetisMM-3: Study Of Elranatamab (PF-06863135) Monotherapy in Participants With Multiple Myeloma Who Are Refractory to at Least One PI, One IMiD and One Anti-CD38 mAb — Beverly Hills, California
- A Study of CLN-619 (Anti-MICA/MICB Antibody) in Patients With Relapsed and Refractory Multiple Myeloma — Phoenix, Arizona
- A Study of Carfilzomib, Lenalidomide, Vorinostat, and Dexamethasone in Relapsed and/or Refractory Multiple Myeloma — Hackensack, New Jersey
Explore by condition: All Multiple Myeloma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.