A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight (NCT05726227)
Long-term Safety and Efficacy of Semaglutide s.c. Once-weekly on Weight Management in Children and Adolescents (Aged 6 to <18 Years) With Obesity or Overweight
🩺 Plain-English Summary (8th-Grade Level)
This study will look at how well semaglutide helps children and teenagers losing weight. This will be tested by comparing the effect on body weight in children and teenagers taking semaglutide in comparison to placebo, a "dummy" medicine. In addition to taking the medicine, the child's parent and the child will have talks with study staff about healthy food choices, how to be more physically active and what your child can do to try to lose weight. The child will either get semaglutide or a "dummy" medicine. Which treatment the child will get is decided by chance. Semaglutide is an approved medicine for type 2 diabetes and weight management in adults. The child will get one injection once a week. The study medicine is injected with a thin needle in the stomach, thighs or upper arms. The study will last for about 2 ½ years (132 weeks).
Who can join: Review the eligibility criteria below.
Location: Neighborhood Healthcare — Escondido, California
Age range: 6 Years to 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (56 Sites)
Showing the first 25 of 56 sites.
- Neighborhood Healthcare — Escondido, California
- Yale School of Medicine — New Haven, Connecticut
- Columbus Research Foundation — Columbus, Georgia
- Eastside Bariatric and Gen Surg — Snellville, Georgia
- Solaris Clinical Research — Meridian, Idaho
- Pennington Biom Res Ctr — Baton Rouge, Louisiana
- Clinical Trials of America LLC — Monroe, Louisiana
- IMA Clinical Research — Monroe, Louisiana
- Barry J. Reiner, MD LLC — Baltimore, Maryland
- Massachusetts General Hospital_Cary — Boston, Massachusetts
- University of Minnesota — Minneapolis, Minnesota
- Mississippi Center for Advanced Medicine — Madison, Mississippi
- Mississippi CTR for ADV MED — Madison, Mississippi
- UBMD Peds-Div of Endo/Diabetes — Buffalo, New York
- WakeMed Childn Endo-Dbt_Raleig — Raleigh, North Carolina
- Valley Weight Loss Clinic — Fargo, North Dakota
- Centricity Research - Ohio — Columbus, Ohio
- UPMC Child Hosp-Pittsburgh — Pittsburgh, Pennsylvania
- Vanderbilt University Medical Center — Nashville, Tennessee
- Pediatric Clinical Trials, LLC — Tullahoma, Tennessee
- Texas Diabetes & Endocrinology — Austin, Texas
- Univ Of Texas Hlth Science Cntr — San Antonio, Texas
- Health Res of Hampton Roads — Newport News, Virginia
- Marshfield Clinic — Marshfield, Wisconsin
- Universitätsklinik Kinder-Jugendheilkunde Innsbruck — Innsbruck,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.