๐๏ธ Verified NIH Record โข Updated 2025-12-05
Evaluation of Tonabersat for DME (NCT05727891)
A Phase 2 Evaluation of Tonabersat for Diabetic Macular Edema (Protocol AN)
๐ต Active, Not Recruiting Phase2 ๐ Investigational Drug / Biologic Sponsor: Jaeb Center for Health Research
๐ฉบ Plain-English Summary (8th-Grade Level)
This randomized clinical trial will evaluate the effect of tonabersat compared with placebo on central subfield thickness (CST) in eyes with center-involved diabetic macular edema (CI-DME) and good visual acuity.
Who can join: Review the eligibility criteria below.
Location: Retina Associates of Southern California โ Huntington Beach, California
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (28 Sites)
Showing the first 25 of 28 sites.
- Retina Associates of Southern California โ Huntington Beach, California
- Loma Linda University โ Loma Linda, California
- East Bay Retina Consultants, Inc. โ Oakland, California
- Southern California Desert Retina Consultants, Inc. โ Palm Desert, California
- Macula Retina Vitreous Institute โ Torrance, California
- National Ophthalmic Research Institute โ Fort Myers, Florida
- University of Florida- Jacksonville โ Jacksonville, Florida
- Central Florida Retina Institute โ Lakeland, Florida
- Florida Retina Consultants โ Lakeland, Florida
- Southeast Eye Institute, P.A. dba Eye Associates of Pinellas โ Pinellas Park, Florida
- Southeast Retina Center โ Augusta, Georgia
- Thomas Eye Group โ Sandy Springs, Georgia
- Illinois Retina Associates โ Oak Park, Illinois
- Midwest Eye Institute โ Indianapolis, Indiana
- Joseph E. Humble and Raymond Haik PTRS DBA Eye Assoc of Northeast Louisiana โ West Monroe, Louisiana
- Elman Retina Group โ Baltimore, Maryland
- Boston Medical Center Corporation โ Boston, Massachusetts
- Joslin Diabetes Center โ Boston, Massachusetts
- Mayo Clinic โ Rochester, Minnesota
- Retina Research Institute, LLC โ St Louis, Missouri
- Retina-Vitreous Surgeons of Central NY, PC โ Liverpool, New York
- Verum Research LLC โ Eugene, Oregon
- The Trustees of the University of Pennsylvania โ Philadelphia, Pennsylvania
- Pittsburg Clinical Trial Consortium โ Sewickley, Pennsylvania
- Hilton Head Retina Institute โ Hilton Head Island, South Carolina
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Diabetic Macular Edema
- Long-Term Follow-up Study of ADVM-022 in DME (INFINITY-EXT) โ Beverly Hills, California
- 4D-150 in Patients With Diabetic Macular Edema โ Hagerstown, Maryland
- Mean Visual Acuity Changes Following Five Injections of Aflibercept โ Hamilton, Ontario
- A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7497372 in Participants With Diabetic Macular Edema (DME) โ Mesa, Arizona
- A Study to Investigate Faricimab Treatment Response in Treatment-Naive, Underrepresented Patients With Diabetic Macular Edema โ Phoenix, Arizona
- A Study to Evaluate Efficacy, Safety & Pharmacokinetics of the Port Delivery System (PDS) With Ranibizumab in Participants With Diabetic Macular Edema (DME) Compared With Intravitreal Ranibizumab; A Substudy to Evaluate the Safety of Re-implanting the PDS With Ranibizumab in Participants With DME โ Mesa, Arizona
Explore by condition: All Diabetic Macular Edema clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.