๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2025-12-05

Evaluation of Tonabersat for DME (NCT05727891)

A Phase 2 Evaluation of Tonabersat for Diabetic Macular Edema (Protocol AN)

๐Ÿ”ต Active, Not Recruiting Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Jaeb Center for Health Research

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This randomized clinical trial will evaluate the effect of tonabersat compared with placebo on central subfield thickness (CST) in eyes with center-involved diabetic macular edema (CI-DME) and good visual acuity.

Who can join: Review the eligibility criteria below.

Location: Retina Associates of Southern California โ€” Huntington Beach, California

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (28 Sites)

Showing the first 25 of 28 sites.

  • Retina Associates of Southern California โ€” Huntington Beach, California
  • Loma Linda University โ€” Loma Linda, California
  • East Bay Retina Consultants, Inc. โ€” Oakland, California
  • Southern California Desert Retina Consultants, Inc. โ€” Palm Desert, California
  • Macula Retina Vitreous Institute โ€” Torrance, California
  • National Ophthalmic Research Institute โ€” Fort Myers, Florida
  • University of Florida- Jacksonville โ€” Jacksonville, Florida
  • Central Florida Retina Institute โ€” Lakeland, Florida
  • Florida Retina Consultants โ€” Lakeland, Florida
  • Southeast Eye Institute, P.A. dba Eye Associates of Pinellas โ€” Pinellas Park, Florida
  • Southeast Retina Center โ€” Augusta, Georgia
  • Thomas Eye Group โ€” Sandy Springs, Georgia
  • Illinois Retina Associates โ€” Oak Park, Illinois
  • Midwest Eye Institute โ€” Indianapolis, Indiana
  • Joseph E. Humble and Raymond Haik PTRS DBA Eye Assoc of Northeast Louisiana โ€” West Monroe, Louisiana
  • Elman Retina Group โ€” Baltimore, Maryland
  • Boston Medical Center Corporation โ€” Boston, Massachusetts
  • Joslin Diabetes Center โ€” Boston, Massachusetts
  • Mayo Clinic โ€” Rochester, Minnesota
  • Retina Research Institute, LLC โ€” St Louis, Missouri
  • Retina-Vitreous Surgeons of Central NY, PC โ€” Liverpool, New York
  • Verum Research LLC โ€” Eugene, Oregon
  • The Trustees of the University of Pennsylvania โ€” Philadelphia, Pennsylvania
  • Pittsburg Clinical Trial Consortium โ€” Sewickley, Pennsylvania
  • Hilton Head Retina Institute โ€” Hilton Head Island, South Carolina

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—