A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZER-ALZ 6) (NCT05738486)
Investigating the Effect of Different Donanemab Dosing Regimens on ARIA-E and Amyloid Lowering in Adults With Early Symptomatic Alzheimer's Disease
🩺 Plain-English Summary (8th-Grade Level)
This study will investigate different donanemab dosing regimens and their effect on the frequency and severity of ARIA-E in adults with early symptomatic Alzheimer's disease (AD) and explore participant characteristics that might predict risk of ARIA. Approximately 375 additional participants will be enrolled in addendum 2. Addendum 3 includes a subset of participants from the main study to receive a single dose. The study will last approximately 91 weeks and include up to 26 visits in the main study.
Who can join: Review the eligibility criteria below.
Location: MD First Research - Chandler — Chandler, Arizona
Age range: 60 Years to 85 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (49 Sites)
Showing the first 25 of 49 sites.
- MD First Research - Chandler — Chandler, Arizona
- Irvine Clinical Research — Irvine, California
- Healthy Brain Clinic — Long Beach, California
- California Neuroscience Research Medical Group, Inc. — Sherman Oaks, California
- JEM Research Institute — Atlantis, Florida
- VIN-Julie Schwartzbard — Aventura, Florida
- Excel Medical Clinical Trials — Boca Raton, Florida
- K2 Medical Research — Clermont, Florida
- Brain Matters Research — Delray Beach, Florida
- Neuropsychiatric Research Center of Southwest Florida — Fort Myers, Florida
- Finlay Medical Research — Greenacres City, Florida
- Infinity Clinical Research, LLC — Hollywood, Florida
- Jacksonville Center for Clinical Research — Jacksonville, Florida
- ClinCloud - Maitland — Maitland, Florida
- K2 Medical Research — Maitland, Florida
- ClinCloud - Viera — Melbourne, Florida
- Suncoast Clinical Research, Inc. — New Port Richey, Florida
- Renstar Medical Research — Ocala, Florida
- Charter Research - Winter Park — Orlando, Florida
- Progressive Medical Research — Port Orange, Florida
- Alzheimer's Research and Treatment Center — Stuart, Florida
- K2 Medical Research - Tampa — Tampa, Florida
- K2 Summit Research — The Villages, Florida
- Charter Research - Lady Lake — The Villages, Florida
- Alzheimer's Research and Treatment Center — Wellington, Florida
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Alzheimer's Disease
- Standardizing Care for Neuropsychiatric Symptoms and Quality of Life in Dementia — Calgary, Alberta
- A Community-Based Screening Program to Identify Participants at High Risk for Amyloid Pathology — Clermont, Florida
- A Study of E2814 With Concurrent Lecanemab Treatment in Participants With Early Alzheimer's Disease — Phoenix, Arizona
- DIAN-TU Amyloid Removal Trial (ART) in Dominantly Inherited Alzheimer's Disease — Birmingham, Alabama
- A Study of Remternetug (LY3372993) in Early Alzheimer's Disease (TRAILRUNNER-ALZ 3) — Birmingham, Alabama
Explore by condition: All Alzheimer's Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.