๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2025-12-11

A Study of Doravirine/Islatravir (DOR/ISL, MK-8591A) for the Treatment of Human Immunodeficiency Virus 1 (HIV-1) Infection in Participants Who Previously Received DOR/ISL (MK-8591A-054) (NCT05766501)

A Phase 3 Open-label Clinical Study of Doravirine/Islatravir (DOR/ISL [100 mg/0.25 mg]) Once Daily for the Treatment of HIV-1 Infection in Participants Who Previously Received DOR/ISL (100 mg/0.75 mg) QD in a Phase 3 Clinical Study

๐Ÿ”ต Active, Not Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Merck Sharp & Dohme LLC

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The purpose of this study is to evaluate the safety and tolerability of DOR/ISL in adult participants with HIV-1 who had been previously treated with DOR/ISL in earlier clinical studies. There are no formal hypotheses to be tested in this study.

Who can join: Review the eligibility criteria below.

Location: University of Alabama at Birmingham-UAB 1917 Research Clinic ( Site 3104) โ€” Birmingham, Alabama

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (95 Sites)

Showing the first 25 of 95 sites.

  • University of Alabama at Birmingham-UAB 1917 Research Clinic ( Site 3104) โ€” Birmingham, Alabama
  • Pueblo Family Physicians ( Site 3102) โ€” Phoenix, Arizona
  • Pacific Oaks Medical Group ( Site 3123) โ€” Beverly Hills, California
  • Kaiser Permanente ( Site 3124) โ€” Los Angeles, California
  • Ruane Clinical Research Group, Inc ( Site 3126) โ€” Los Angeles, California
  • Mills Clinical Research ( Site 3114) โ€” Los Angeles, California
  • University of California Davis Health-Internal Medicine: Infectious Diseases ( Site 3137) โ€” Sacramento, California
  • Georgetown University Medical Center ( Site 3130) โ€” Washington D.C., District of Columbia
  • Therafirst Medical Center ( Site 3110) โ€” Fort Lauderdale, Florida
  • Midway Immunology and Research Center ( Site 3117) โ€” Ft. Pierce, Florida
  • AHF The Kinder Medical Group ( Site 3108) โ€” Miami, Florida
  • Floridian Clinical Research, LLC ( Site 3133) โ€” Miami Lakes, Florida
  • Orlando Immunology Center ( Site 3106) โ€” Orlando, Florida
  • Bliss Healthcare Services ( Site 3115) โ€” Orlando, Florida
  • CAN Community Health - Sarasota ( Site 3118) โ€” Sarasota, Florida
  • Triple O Research Institute, P.A ( Site 3116) โ€” West Palm Beach, Florida
  • Augusta University-Infectious Diseases ( Site 3135) โ€” Augusta, Georgia
  • Infectious Disease Specialists of Atlanta ( Site 3128) โ€” Decatur, Georgia
  • Mercer university, Department of internal medicine-Clinical Research ( Site 3129) โ€” Macon, Georgia
  • Chatham County Health Department - Chatham CARE Center-Infectious Disease ( Site 3105) โ€” Savannah, Georgia
  • KC CARE Health Center ( Site 3103) โ€” Kansas City, Missouri
  • ID Care ( Site 3131) โ€” Hillsborough, New Jersey
  • Icahn School of Medicine at Mount Sinai-Clinical and Translational Research Center ( Site 3134) โ€” New York, New York
  • Penn Medicine: University of Pennsylvania Health System-Perelman Center for Advanced Medicine ( Site โ€” Philadelphia, Pennsylvania
  • St Hope Foundation ( Site 3121) โ€” Bellaire, Texas

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All HIV Infection clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—