A Study of Doravirine/Islatravir (DOR/ISL, MK-8591A) for the Treatment of Human Immunodeficiency Virus 1 (HIV-1) Infection in Participants Who Previously Received DOR/ISL (MK-8591A-054) (NCT05766501)
A Phase 3 Open-label Clinical Study of Doravirine/Islatravir (DOR/ISL [100 mg/0.25 mg]) Once Daily for the Treatment of HIV-1 Infection in Participants Who Previously Received DOR/ISL (100 mg/0.75 mg) QD in a Phase 3 Clinical Study
๐ฉบ Plain-English Summary (8th-Grade Level)
The purpose of this study is to evaluate the safety and tolerability of DOR/ISL in adult participants with HIV-1 who had been previously treated with DOR/ISL in earlier clinical studies. There are no formal hypotheses to be tested in this study.
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham-UAB 1917 Research Clinic ( Site 3104) โ Birmingham, Alabama
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (95 Sites)
Showing the first 25 of 95 sites.
- University of Alabama at Birmingham-UAB 1917 Research Clinic ( Site 3104) โ Birmingham, Alabama
- Pueblo Family Physicians ( Site 3102) โ Phoenix, Arizona
- Pacific Oaks Medical Group ( Site 3123) โ Beverly Hills, California
- Kaiser Permanente ( Site 3124) โ Los Angeles, California
- Ruane Clinical Research Group, Inc ( Site 3126) โ Los Angeles, California
- Mills Clinical Research ( Site 3114) โ Los Angeles, California
- University of California Davis Health-Internal Medicine: Infectious Diseases ( Site 3137) โ Sacramento, California
- Georgetown University Medical Center ( Site 3130) โ Washington D.C., District of Columbia
- Therafirst Medical Center ( Site 3110) โ Fort Lauderdale, Florida
- Midway Immunology and Research Center ( Site 3117) โ Ft. Pierce, Florida
- AHF The Kinder Medical Group ( Site 3108) โ Miami, Florida
- Floridian Clinical Research, LLC ( Site 3133) โ Miami Lakes, Florida
- Orlando Immunology Center ( Site 3106) โ Orlando, Florida
- Bliss Healthcare Services ( Site 3115) โ Orlando, Florida
- CAN Community Health - Sarasota ( Site 3118) โ Sarasota, Florida
- Triple O Research Institute, P.A ( Site 3116) โ West Palm Beach, Florida
- Augusta University-Infectious Diseases ( Site 3135) โ Augusta, Georgia
- Infectious Disease Specialists of Atlanta ( Site 3128) โ Decatur, Georgia
- Mercer university, Department of internal medicine-Clinical Research ( Site 3129) โ Macon, Georgia
- Chatham County Health Department - Chatham CARE Center-Infectious Disease ( Site 3105) โ Savannah, Georgia
- KC CARE Health Center ( Site 3103) โ Kansas City, Missouri
- ID Care ( Site 3131) โ Hillsborough, New Jersey
- Icahn School of Medicine at Mount Sinai-Clinical and Translational Research Center ( Site 3134) โ New York, New York
- Penn Medicine: University of Pennsylvania Health System-Perelman Center for Advanced Medicine ( Site โ Philadelphia, Pennsylvania
- St Hope Foundation ( Site 3121) โ Bellaire, Texas
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in HIV Infection
- Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving Stem Cell Transplant โ La Jolla, California
- Safety, Tolerability, and Efficacy of IL-15 Superagonist (N-803) With and Without Combination Broadly Neutralizing Antibodies to Induce HIV-1 Control During Analytic Treatment Interruption โ Birmingham, Alabama
- Baricitinib Curative Repression of HIV-1 โ Atlanta, Georgia
- Duo: A Phase IIIb Individual-Level Randomized Controlled Trial of an Integrated Strategy โ Los Angeles, California
- Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV: A Feasibility Study โ La Jolla, California
Explore by condition: All HIV Infection clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.