HIP Fracture Oral ThromboPROphylaxis (Hip PRO Pilot) (NCT05775965)
HIP Fracture Oral ThromboPROphylaxis: a Pilot Randomized Controlled Trial (Hip PRO Pilot)
🩺 Plain-English Summary (8th-Grade Level)
As our Canadian population ages, hip fractures in these older adults are becoming very common. The best treatment for the majority of these injuries is urgent treatment with surgery. However, the hip fracture itself, the surgery required, and the immobility following these injuries are all risk factors for developing blood clots in the legs (deep vein thrombosis or DVT) and blood clots in the lungs (pulmonary embolism or PE). These complications are a common cause of death in patients with hip fractures and often result in prolonged medical treatment and hospital stays. Patients with hip fractures who require surgery are traditionally given injectable blood thinners to help prevent blood clots; however, these medications are costly, may not be tolerated well, and can be difficult to take, as prescribed. Oral blood thinning medications are being used more commonly, but it is unknown which of these medications is the most effective in preventing blood clots in patients after a hip fracture. Thrombelastography (TEG) technology uses a small sample of blood to evaluate a person's clotting ability. Our research has used TEG technology to evaluate blood clotting risk after hip fracture surgery and the investigators have found that platelets may play an important role in abnormal blood clotting after a hip fracture. The investigators have also shown that acetylsalicylic acid (ASA or Aspirin) may help reduce the abnormal platelet hyperactivity associated with blood clotting. This medication warrants investigation for blood clot prevention after hip fracture. The investigators propose to directly compare different oral medication regimens after hip fracture surgery, in order to determine which is safest and most effective in preventing blood clots. Our multi-disciplinary research team includes physicians, surgeons, and scientists with experience evaluating different medications for blood clot prevention. Our results will help determine the best medical treatment for preventing DVT and PE, which will benefit patients with hip fractures worldwide.
Who can join: Review the eligibility criteria below.
Location: Foothills Medical Centre — Calgary, Alberta
Age range: 50 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (3 Sites)
- Foothills Medical Centre — Calgary, Alberta
- Royal Columbian Hospital — New Westminster, British Colombia
- The Ottawa Hospital — Ottawa, Ontario
📞 Contact the Study Coordinator
Phone: (403) 944-4518
Email: prism.schneider@albertahealthservices.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Hip Fractures
- The Role of Blood Flow Restriction Therapy in Postoperative Elderly Patients With Hip Fracture — Birmingham, Alabama
- Effect of Tranexamic Acid (TXA) on Reduction of Postoperative Blood Transfusion — Toledo, Ohio
- Endoprosthetic Replacement for Pathological Fractures of the Hip: A 35-year Update — New York, New York
- Go Fit Fast, Recovery Trajectory Using PROMIS®, Linking PROMIS® — Los Angeles, California
- PENG vs Femoral Block for Hip Fracture Analgesia — Manhattan, New York
- Comparison of Cryoablation of Pericapsular Nerve Group (PENG) to Fascia Iliaca Catheter in Patients With a Hip Fracture — Minneapolis, Minnesota
Explore by condition: All Hip Fractures clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.