Methylphenidate for the Treatment of PTSD With Associated Neurocognitive Complaints (NCT05776056)
Randomized Placebo-Controlled Trial of Methylphenidate for the Treatment of Post-Traumatic Stress Disorder With Associated Neurocognitive Complaints
🩺 Plain-English Summary (8th-Grade Level)
Posttraumatic stress disorder (PTSD) is frequently accompanied by difficulty concentrating, poor memory, and inability to keep up with tasks, which negatively impacts a person's ability to function at work and in relationships. Currently available treatments do not fully relieve all symptoms. A published research report showed positive evidence that the stimulant medication methylphenidate was beneficial in treating these problems. This study will evaluate the ability of methylphenidate to treat PTSD and associated neurocognitive complaints in Veterans. An innovative feature is the study's N-of-1 design. In this design, every participant will move back and forth every 4-5 weeks between treatment with methylphenidate and treatment with placebo, in random order and under double-blind conditions, over a 20-week period. The investigators will compare the aggregated change in PTSD and neurocognitive symptoms between periods of treatment with methylphenidate versus placebo. Results will help clinicians to better choose the best treatment for Veterans living with PTSD.
Who can join: Review the eligibility criteria below.
Location: Birmingham VA Medical Center, Birmingham, AL — Birmingham, Alabama
Age range: 18 Years to 65 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (3 Sites)
- Birmingham VA Medical Center, Birmingham, AL — Birmingham, Alabama
- Tuscaloosa VA Medical Center, Tuscaloosa, AL — Tuscaloosa, Alabama
- VA Puget Sound Health Care System Seattle Division, Seattle, WA — Seattle, Washington
📞 Contact the Study Coordinator
Phone: (206) 277-5054
Email: Rebecca.Hendrickson@va.gov
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Posttraumatic Stress Disorder (PTSD)
- Adaptation and Randomized Controlled Trial of Written Exposure Therapy for Adolescents — Charleston, South Carolina
- Open Pilot Trial of Adapted Cognitive Processing Therapy for Comorbid PTSD and Opioid Use Disorder — New York, New York
- Predictors & Mechanisms of Adolescent PTSD — Charleston, South Carolina
- EEG and Actigraphy Biomarkers of Written Exposure Therapy for Posttraumatic Stress Disorder — Belmont, Massachusetts
- Extended Group Written Exposure Therapy for Comorbid PTSD and BPD (Traits) — Hamilton, Ontario
- Personalized Repetitive Transcranial Magnetic Stimulation (PrTMS) for Treatment of Post-Traumatic Stress Disorder (PTSD) — Charlestown, Massachusetts
Explore by condition: All Posttraumatic Stress Disorder (PTSD) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.