Reversibility of Brain Glucose Transport in Type 2 Diabetes Mellitus (T2DM) (NCT05776563)
Reversibility of Brain Glucose Transport and Metabolism in T2DM
🩺 Plain-English Summary (8th-Grade Level)
The goal of this clinical trial is to learn about the effects of high blood glucose levels in the brain and assess if the changes seen in individuals with poorly control T2DM can be reversed with good glucose control. The main question\[s\] it aims to answer are: * To determine, whether abnormalities in brain glucose transport seen in individuals with uncontrolled diabetes, can be improved with better glucose control. * Assess which factors, (duration of diabetes mellitus (DM) and glycemic control) contribute to changes in glucose transport Participants will have: * A screening visit * placement of a continuous glucose monitor (CGM) 2 weeks before the first magnetic resonance spectroscopy (MRS) at week 0 * Additional visits/phone calls for intensification of diabetes management and nutrition visits * Second magnetic resonance spectroscopy (MRS) at week 12
Who can join: Review the eligibility criteria below.
Location: Yale New Haven Hospital (YNHH) Research Unit (HRU) — New Haven, Connecticut
Age range: 18 Years to 60 Years
🧪 Interventions in This Study
- Nutrition visits (BEHAVIORAL)
- Intensification of diabetes regimen (OTHER)
- Continuous glucose monitor (CGM) (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Yale New Haven Hospital (YNHH) Research Unit (HRU) — New Haven, Connecticut
📞 Contact the Study Coordinator
Phone: (203) 785-6430
Email: elizabeth.sanchezrangel@yale.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.