🏛️ Verified NIH Record • Updated 2025-03-25

Study of TU2218 in Combination With KEYTRUDA®(Pembrolizumab) in Patients With Advanced Solid Tumors (NCT05784688)

A Phase 1b/2a Study to Assess the Safety, Pharmacokinetics, and Preliminary Efficacy of TU2218, an Oral TGFβR Serine/Threonine Kinase Inhibitor, Administered in Combination With Pembrolizumab in Patients With Advanced Solid Tumors

🟢 Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic Sponsor: TiumBio Co., Ltd.

🩺 Plain-English Summary (8th-Grade Level)

This study consists of phase 1b and 2a to evaluate safety, Pharmacokinetics, and efficacy of TU2218 in combination with Pembrolizumab in patients with advanced solid tumors.

Who can join: Review the eligibility criteria below.

Location: NEXT Oncology — San Antonio, Texas

Age range: 18 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (11 Sites)

  • NEXT Oncology — San Antonio, Texas
  • Hope Cancer Center — Tyler, Texas
  • Medical Oncology — Spokane, Washington
  • CHA University Bundang Medical Center — Seongnam,
  • Seoul National University Bundang Hospital — Seongnam,
  • Asan Medical Center — Seoul,
  • Samsung Medical Center — Seoul,
  • Seoul National University Hospital — Seoul,
  • Severance Hospital — Seoul,
  • The Catholic University of Korea Seoul St. Mary Hospital — Seoul,
  • The Catholic University of Korea St. Vincent's Hospital — Suwon,

📞 Contact the Study Coordinator

Phone: 82-31-600-1500

Email: nce401_tu2218@tiumbio.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Solid Tumor clinical trials

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗