A Phase 1-2 of ST316 With Selected Advanced Unresectable and Metastatic Solid Tumors (NCT05848739)
A Phase 1-2 Dose-escalation and Expansion Study of ST316 in Subjects With Selected Advanced Unresectable and Metastatic Solid Tumors
๐ฉบ Plain-English Summary (8th-Grade Level)
This is an open-label, two-part, phase 1-2 study designed to determine the safety, tolerability, PK, pharmacodynamics (PD), and proof-of-concept efficacy of ST316 administered IV in subjects with selected advanced solid tumors likely to harbor abnormalities of the WNT/ฮฒ-catenin signaling pathway. The study consists of two phases: a phase 1 dose escalation/regimen exploration phase and a phase 2 expansion phase.
Who can join: Review the eligibility criteria below.
Location: University of Alabama โ Birmingham, Alabama
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (11 Sites)
- University of Alabama โ Birmingham, Alabama
- USC Norris Comprehensive Cancer Center โ Los Angeles, California
- Sarah Cannon Research Institute - CO โ Denver, Colorado
- Ochsner Clinic Foundation โ New Orleans, Louisiana
- Beth Israel Deaconess Medical Center โ Boston, Massachusetts
- START Midwest โ Grand Rapids, Michigan
- Westchester Medical Center โ Valhalla, New York
- Duke Universtiy โ Durham, North Carolina
- OU Health Stephenson Cancer Center โ Oklahoma City, Oklahoma
- Sanford Cancer Center โ Sioux Falls, South Dakota
- Fred Hutch Cancer Center โ Seattle, Washington
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.