🏛️ Verified NIH Record • Updated 2026-08-04

Study of MK-0472 in Participants With Advanced/Metastatic Solid Tumors (MK-0472-001) (NCT05853367)

A Phase 1/1b Open-label, Multicenter Clinical Study of MK-0472 as Monotherapy and Combination Therapy in Participants With Advanced/Metastatic Solid Tumors.

🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: Merck Sharp & Dohme LLC

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to assess the efficacy, safety, and tolerability of MK-0472 administered as monotherapy and in combination with pembrolizumab (MK-3475) or MK-1084 in participants with histologically or cytologically confirmed diagnosis of advanced/metastatic solid tumors.

Who can join: Review the eligibility criteria below.

Location: Northwestern Memorial Hospital ( Site 0002) — Chicago, Illinois

Age range: 18 Years

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (25 Sites)

  • Northwestern Memorial Hospital ( Site 0002) — Chicago, Illinois
  • The University of Louisville, James Graham Brown Cancer Center ( Site 0004) — Louisville, Kentucky
  • John Theurer Cancer Center at Hackensack University Medical Center ( Site 0001) — Hackensack, New Jersey
  • Rutgers Cancer Institute of New Jersey ( Site 0005) — New Brunswick, New Jersey
  • Princess Margaret Cancer Centre ( Site 0101) — Toronto, Ontario
  • Centre Hospitalier de l'Université de Montréal-Unit for Innovative Therapies ( Site 0100) — Montreal, Quebec
  • Département clinique de médecine de laboratoire du CHUM ( Site 0104) — Montreal, Quebec
  • Centro de Estudios Clínicos SAGA ( Site 0701) — Santiago, Region M. de Santiago
  • Fundacion Arturo Lopez Perez ( Site 0700) — Santiago, Region M. de Santiago
  • Centro de Investigacion Clinicadela Universidad Catolica ( Site 0703) — Santiago, Region M. de Santiago
  • Bradfordhill ( Site 0702) — Santiago, Region M. de Santiago
  • Rambam Health Care Campus ( Site 0304) — Haifa,
  • Shaare Zedek Medical Center ( Site 0303) — Jerusalem,
  • Rabin Medical Center ( Site 0301) — Petah Tikva,
  • Sheba Medical Center ( Site 0300) — Ramat Gan,
  • Sourasky Medical Center ( Site 0302) — Tel Aviv,
  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 0401) — Warsaw, Masovian Voivodeship
  • Uniwersyteckie Centrum Kliniczne ( Site 0400) — Gdansk, Pomeranian Voivodeship
  • Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 0501) — L'Hospitalet de Llobregat, Catalonia
  • Centro Integral Oncologico Clara Campal-Hospital HM Universitario Sanchinarro-START Madrid, ( Site 0504) — Madrid, Madrid, Comunidad de
  • Hospital Universitari Vall d'Hebron ( Site 0500) — Barcelona,
  • Hospital Virgen del Rocio ( Site 0503) — Seville,
  • Hôpitaux Universitaires de Genève (HUG) ( Site 0202) — Geneva, Canton of Geneva
  • Cantonal Hospital St.Gallen-Oncology & Hematology ( Site 0201) — Sankt Gallen, Canton of St. Gallen
  • Ospedale Regionale Bellinzona e Valli ( Site 0200) — Bellinzona, Canton Ticino

📞 Contact the Study Coordinator

Phone: (855) 692-6482

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗