Conventionally Fractionated vs. Hypofractionated Comprehensive Nodal Irradiation for Breast Cancer Using Pencil Beam Scanning Proton Therapy (NCT05856773)
Phase III Randomized Trial of Conventionally Fractionated vs. Hypofractionated COMprehensive Nodal Irradiation for Breast Cancer Using Pencil Beam Scanning PROton Therapy (COMPRO)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this research study is to learn more about the effects of using proton radiation therapy delivered over a shorter course of treatment (3 weeks) compared with a longer, standard course of treatment (5 weeks) for women with breast cancer who require radiotherapy to the breast/chest wall and regional lymph nodes.
Who can join: Review the eligibility criteria below.
Location: Mayo Clinic — Scottsdale, Arizona
Age range: 19 Years
🧪 Interventions in This Study
- Proton Therapy (RADIATION)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (9 Sites)
- Mayo Clinic — Scottsdale, Arizona
- California Protons Cancer Therapy Center — San Diego, California
- University of Florida Proton Therapy Institute — Jacksonville, Florida
- Dwoskin Proton Therapy Center — Miami, Florida
- Miami Cancer Institute — Miami, Florida
- Emory Proton Therapy Center — Atlanta, Georgia
- Maryland Proton Treatment Center — Baltimore, Maryland
- New York Proton Center — New York, New York
- Inova Schar Cancer Institute — Fairfax, Virginia
📞 Contact the Study Coordinator
Phone: (855) 776-0015
Email: leonard.june@mayo.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.