Focused Radiation Versus Systemic Therapy for Kidney Cancer Patients With Limited Metastasis, SOAR Study (NCT05863351)
Phase III Randomized Trial of Stereotactic Ablative Radiotherapy (SAbR) for Oligometastatic Advanced Renal Carcinoma (SOAR)
🩺 Plain-English Summary (8th-Grade Level)
This phase III trial compares the effect of stero-ablative radiotherapy (SAbR) followed by standard of care systemic therapy, to standard of care systemic therapy alone, in patients with kidney cancer that has spread from where it first started (primary site) to a limited (2-5) number of places in the body (metastatic). Study doctors want to find out if this approach is better or worse than the usual approach for metastatic kidney cancer. The usual approach is defined as the care most people get for metastatic kidney cancer which includes systemic therapy such as immunotherapy (given through the veins) and/or small molecular inhibitor (tablets taken by mouth). Radiotherapy uses high energy x-rays to kill cancer cells and shrink tumors. SAbR uses special equipment to position a patient and deliver radiation to tumors with high precision. Giving SAbR prior to systemic therapy may kill more tumor cells than the usual approach, which is systemic therapy alone.
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
Age range: 18 Years
🧪 Interventions in This Study
- Computed Tomography (PROCEDURE)
- Magnetic Resonance Imaging (PROCEDURE)
- Questionnaire Administration (OTHER)
- Stereotactic Ablative Radiotherapy (PROCEDURE)
- Systemic Therapy (PROCEDURE)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (108 Sites)
Showing the first 25 of 108 sites.
- University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
- Mayo Clinic Hospital in Arizona — Phoenix, Arizona
- UCHealth University of Colorado Hospital — Aurora, Colorado
- Poudre Valley Hospital — Fort Collins, Colorado
- Cancer Care and Hematology-Fort Collins — Fort Collins, Colorado
- UCHealth Greeley Hospital — Greeley, Colorado
- UCHealth Highlands Ranch Hospital — Highlands Ranch, Colorado
- Medical Center of the Rockies — Loveland, Colorado
- Sibley Memorial Hospital — Washington D.C., District of Columbia
- Mayo Clinic in Florida — Jacksonville, Florida
- OSF Saint Joseph Medical Center — Bloomington, Illinois
- Illinois CancerCare-Bloomington — Bloomington, Illinois
- Illinois CancerCare-Canton — Canton, Illinois
- Illinois CancerCare-Carthage — Carthage, Illinois
- Centralia Oncology Clinic — Centralia, Illinois
- Northwestern University — Chicago, Illinois
- University of Illinois — Chicago, Illinois
- Carle at The Riverfront — Danville, Illinois
- Cancer Care Specialists of Illinois - Decatur — Decatur, Illinois
- Decatur Memorial Hospital — Decatur, Illinois
- Northwestern Medicine Cancer Center Kishwaukee — DeKalb, Illinois
- Carle Physician Group-Effingham — Effingham, Illinois
- Crossroads Cancer Center — Effingham, Illinois
- Illinois CancerCare-Eureka — Eureka, Illinois
- Illinois CancerCare-Galesburg — Galesburg, Illinois
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Metastatic Renal Cell Carcinoma
- A Phase II Study Bolstering Outcomes by Optimizing Immunotherapy Strategies With Evolocumab and Nivolumab in Patients With Metastatic Renal Cell Carcinoma (BOOST-RCC) — Dallas, Texas
- Nivolumab in Treating Patients With Localized Kidney Cancer Undergoing Nephrectomy — Birmingham, Alabama
- A Study of Cabozantinib and Nivolumab With Radiation Therapy for People With Renal Cell Carcinoma That Has Spread to the Brain — Basking Ridge, New Jersey
- A Study to Compare Treatments for a Type of Kidney Cancer Called TFE/Translocation Renal Cell Carcinoma (tRCC) — Birmingham, Alabama
- App-Based Mindfulness Intervention for the Improvement of Quality of Life in Patients With Metastatic Renal Cell Cancer — Duarte, California
Explore by condition: All Metastatic Renal Cell Carcinoma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.