A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities (NCT05869903)
A Phase 3, Randomized, Double-Blind Study to Investigate the Efficacy and Safety of Once-Daily Oral Orforglipron Compared With Placebo in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-1)
🩺 Plain-English Summary (8th-Grade Level)
This study will investigate the efficacy and safety of once daily oral orforglipron in adult participants with obesity or overweight with weight-related comorbidities. The study has two phases: a main phase and an extension phase. The main phase of the study lasted 72 weeks. Participants with prediabetes will continue in the extension for another 2 years.
Who can join: Review the eligibility criteria below.
Location: The Institute for Liver Health II dba Arizona Clinical Trials - Mesa — Chandler, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (138 Sites)
Showing the first 25 of 138 sites.
- The Institute for Liver Health II dba Arizona Clinical Trials - Mesa — Chandler, Arizona
- Clinical Research Institute of Arizona (CRI) - Sun City West — Sun City West, Arizona
- John Muir Physician Network Research Center — Concord, California
- AMCR Institute — Escondido, California
- NorCal Medical Research, Inc — Greenbrae, California
- Velocity Clinical Research, Huntington Park — Huntington Park, California
- Velocity Clinical Research, Westlake — Los Angeles, California
- Catalina Research Institute, LLC — Montclair, California
- Norcal Endocrinology & Internal Medicine — San Ramon, California
- University Clinical Investigators, Inc. — Tustin, California
- University of Colorado Anschutz Medical Campus — Aurora, Colorado
- New Age Medical Research Corporation — Miami, Florida
- South Broward Research — Miramar, Florida
- Renstar Medical Research — Ocala, Florida
- Jedidiah Clinical Research - Tampa - Bay Plaza — Tampa, Florida
- Clinical Site Partners, LLC dba Flourish Research — Winter Park, Florida
- Physicians Research Associates — Lawrenceville, Georgia
- East Coast Institute for Research, LLC — Macon, Georgia
- Rophe Adult and Pediatric Medicine/SKYCRNG — Union City, Georgia
- East-West Medical Research Institute — Honolulu, Hawaii
- Elite Clinical Trials — Blackfoot, Idaho
- Cotton O'Neil Clinical Research Center — Topeka, Kansas
- Cotton O'Neil Diabetes & Endocrinology — Topeka, Kansas
- Pennington Biomedical Research Center — Baton Rouge, Louisiana
- Care Access - Lake Charles — Lake Charles, Louisiana
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.