AMP SCZ® Observational Study: PREDICT-DPACC (NCT05905003)
Accelerating Medicines Partnership® Schizophrenia Observational Study: Psychosis Risk Evaluation, Data Integration, and Computational Technologies -Data Processing, Analysis, and Coordination Center and Coordination Center
🩺 Plain-English Summary (8th-Grade Level)
The Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) is a large international collaboration to develop algorithms using a set of clinical and cognitive assessments, multi-modal biomarkers, and clinical endpoints that can be used to predict the trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the testing of pharmacological interventions for CHR individuals in need. The goal is to accurately predict which individuals are likely to remit, experience an acute psychotic episode, or have intermediate outcomes that feature persistent attenuated psychotic and/or mood symptoms along with functional impairment. The prediction algorithms will have the potential to serve as early indicators of treatment efficacy in CHR persons. The AMP SCZ research program is made up of the Psychosis Risk Evaluation, Data Integration, and Computational Technologies - Data Processing, Analysis and Coordination Center (PREDICT-DPACC) and two clinical research networks, the Psychosis-Risk Outcomes Network (ProNET) and the Trajectories and Predictors in the Clinical High Risk for Psychosis Population: Prediction Scientific Global Consortium (PRESCIENT) networks. The two clinical research networks will recruit a large cohort of CHR young people aged 12-30 years (n=1,977) and healthy control (HC) participants (n=640) across 42 participating investigative sites from 13 countries. CHR participants will complete screening, baseline assessments and a battery of follow-up assessments across 18 - 24 months. HC participants will complete screening and baseline assessments and a subset (5 per site) will complete month 2, 12 and 24 visits.
Who can join: Review the eligibility criteria below.
Location: University of California Irvine — Irvine, California
Age range: 12 Years to 30 Years
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (42 Sites)
Showing the first 25 of 42 sites.
- University of California Irvine — Irvine, California
- University of California Los Angeles — Los Angeles, California
- University of California San Diego — San Diego, California
- University of California San Francisco — San Francisco, California
- Hartford Healthcare — Hartford, Connecticut
- Yale University/Connecticut Mental Health Center — New Haven, Connecticut
- University of Georgia — Athens, Georgia
- Northwestern University — Evanston, Illinois
- Beth Israel Deaconess Medical Center — Boston, Massachusetts
- Washington University — St Louis, Missouri
- Icahn School of Medicine at Mount Sinai — New York, New York
- Northwell Health — Queens, New York
- University of North Carolina at Chapel Hill — Chapel Hill, North Carolina
- University of Oregon — Eugene, Oregon
- University of Pennsylvania — Philadelphia, Pennsylvania
- Temple University — Philadelphia, Pennsylvania
- University of Pittsburgh — Pittsburgh, Pennsylvania
- HEP and co-located Headspace Adelaide — Adelaide, South Australia
- Headspace, Craigieburn — Craigieburn, Victoria
- Headspace, Glenroy — Glenroy, Victoria
- Headspace Melton — Melton South, Victoria
- Orygen Specialist Programs, Melbourne — Parkville, Victoria
- Headspace, Sunshine — Sunshine, Victoria
- Headspace, Werribee — Werribee, Victoria
- University of Calgary — Calgary, Alberta
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.