๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-07-01

Study of Tinengotinib VS. Physician's Choice a Treatment of Subjects With FGFR-altered in Cholangiocarcinoma (NCT05948475)

A Phase III, Randomized, Controlled, Global Multicenter Study to Evaluate the Efficacy and Safety of Oral Tinengotinib VS Physician's Choice in Subjects With FGFR-altered, Chemotherapy- and FGFR Inhibitor-Cholangiocarcinoma

๐Ÿ”ต Active, Not Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: TransThera Sciences (Nanjing), Inc.

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This study is a Phase III, Randomized, Controlled, Global Multicenter Study to Evaluate the Efficacy and Safety of Oral Tinengotinib versus Physician's Choice in Subjects with Fibroblast Growth Factor Receptor (FGFR)-altered, Chemotherapy- and FGFR Inhibitor-Refractory/Relapsed Cholangiocarcinoma

Who can join: Review the eligibility criteria below.

Location: UCLA Medical Center โ€” Santa Monica, California

Age range: 18 Years

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (87 Sites)

Showing the first 25 of 87 sites.

  • UCLA Medical Center โ€” Santa Monica, California
  • Stanford Cancer Center โ€” Stanford, California
  • The University of Kansas Cancer Center โ€” Westwood, Los Angeles, California
  • Mount Sinai Comprehensive Cancer Center โ€” Miami Beach, Florida
  • The University of Chicago Hospitals โ€” Chicago, Illinois
  • UMass Memorial Medical Center โ€” Worcester, Massachusetts
  • University of Michigan โ€” Ann Arbor, Michigan
  • Henry Ford โ€” Detroit, Michigan
  • University of Minnesota- Masonic Cancer Center, M Health Fairview โ€” Minneapolis, Minnesota
  • Roswell Park Comprehensive Cancer Center โ€” Buffalo, New York
  • Messino Cancer Centers โ€” Asheville, North Carolina
  • University Hospitals Cleveland Medical Center โ€” Cleveland, Ohio
  • Tennessee Oncology- Nashville โ€” Nashville, Tennessee
  • Vanderbilt-Ingram Cancer Center โ€” Nashville, Tennessee
  • University of Texas Southwestern Medical Center โ€” Dallas, Texas
  • Texas Oncology-Sammons Cancer Center โ€” Dallas, Texas
  • The University of Texas MD Anderson Cancer Center โ€” Houston, Texas
  • University of Virginia Cancer Center โ€” Charlottesville, Virginia
  • Medical College of Wisconsin โ€” Milwaukee, Wisconsin
  • Ordensklinikum Linz GmbH โ€” Linz,
  • Landesklinikum Wiener Neustadt โ€” Wiener Neustadt,
  • Universitair Ziekenhuis Antwerpen โ€” Antwerp,
  • Universitair Ziekenhuis Gent โ€” Ghent,
  • Universitair Ziekenhuis Leuven โ€” Leuven,
  • Institut Sainte Catherine - Institut du Cancer Avignon Provence โ€” Avignon,

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—