Rapalog Pharmacology (RAP PAC) Study (NCT05949658)
Safer mTOR Inhibition for Human Geroprotection
🩺 Plain-English Summary (8th-Grade Level)
The objective of RAP PAC is to identify safe and effective weekly dose(s) for the mTOR inhibitors sirolimus and everolimus that intervene on the underlying fundamental biology of aging. Participants who are 55-89 years old that are free of overt chronic diseases will be assigned to either 6 weeks of sirolimus or everolimus (5 mg, 10 mg, or 15 mg once per week). The investigators will complete the everolimus arm first and then subsequently complete the sirolimus arm of the study. Total time on study would be up to 17 weeks to complete baseline and follow up visits.
Who can join: Review the eligibility criteria below.
Location: University of Wisconsin — Madison, Wisconsin
Age range: 55 Years to 89 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- University of Wisconsin — Madison, Wisconsin
📞 Contact the Study Coordinator
Phone: (608) 263-2386
Email: rap_pac@medicine.wisc.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Aging
- A Pilot Study on Reverse Aging (The REVERSE Study) — Cincinnati, Ohio
- Feasibility of Home-based tES for Older Adults at Risk of Falling — Roslindale, Massachusetts
- Heat, Microvascular Function and Aging — Milwaukee, Wisconsin
- Protein Quantity and Quality in Older Subjects — Hamilton, Ontario
- Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse — Salt Lake City, Utah
- Effect of a Daily Supplement on Plasma PAI-1 Levels — Los Angeles, California
Explore by condition: All Aging clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.