A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors (NCT05985161)
A Multi-Center Phase II Study of Selinexor in Treating Recurrent or Refractory Wilms Tumor and Other Pediatric Solid Tumors
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to find out whether selinexor is an effective treatment for people who have a relapsed/refractory Wilms tumor, rhabdoid tumor, MPNST, BCOR-driven sarcoma, or another solid tumor that makes a higher than normal amount of XPO1 or has genetic changes that increase the activity of XP01.
Who can join: Review the eligibility criteria below.
Location: Children's Hospital of Los Angeles (Data Collection Only) — Los Angeles, California
Age range: 12 Months
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (16 Sites)
- Children's Hospital of Los Angeles (Data Collection Only) — Los Angeles, California
- Stanford Medicine Children's Health (Data Collection Only) — Palo Alto, California
- Children's National Hospital (Data Collection Only) — Washington D.C., District of Columbia
- Children's Healthcare of Atlanta (Data Collection and Specimen Analysis) — Atlanta, Georgia
- Ann & Robert H. Lurie Children'S Hospital of Chicag — Chicago, Illinois
- Dana Farber Cancer Institute (Data Collection Only) — Boston, Massachusetts
- Washington University — St Louis, Missouri
- Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities) — Basking Ridge, New Jersey
- Memorial Sloan Kettering Monmouth (Limited Protocol Activities) — Middletown, New Jersey
- Memorial Sloan Kettering Bergen (Limited protocol activities) — Montvale, New Jersey
- Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities ) — Commack, New York
- Memorial Sloan Kettering Westchester (Limited Protocol Activities) — Harrison, New York
- Memorial Sloan Kettering Cancer Center (All protocol activites) — New York, New York
- Memorial Sloan Kettering Nassau (Limited protocol activities) — Rockville Centre, New York
- Cincinnati Children's Hospital Medical Center (Data collection only) — Cincinnati, Ohio
- Cook Children's Health Care System (Data Collection Only) — Fort Worth, Texas
📞 Contact the Study Coordinator
Phone: (323) 660-2450
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.